FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007109404> ?p ?o ?g. }

• W3007109404 endingPage "107511" @default.
• W3007109404 startingPage "107511" @default.
• W3007109404 abstract "Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood vessels from an aberrant wound healing response to organ injury or insult. Established fibrosis becomes a hallmark of chronic disease progression and a key contributor to tissue stiffness and dysfunction, which ultimately leads to heart failure. As wound healing and fibrotic responses to myocardial injury are multifactorial processes, current therapies that only target specific contributing factors to disease pathogenesis offer limited overall anti-fibrotic efficacy. As such, recent attention has turned to targeting the body's immune system, which orchestrates the wound healing response to tissue injury. This review focuses on the increasing body of work that has identified the NLRP3 inflammasome, a multiprotein oligomer complex responsible for activation of inflammatory responses via its production of IL-1β and IL-18, as an immune system-initiated facilitator of cardiovascular healing, but also an important contributor to tissue scarring following its persistent activation. The review summarises the factors that can elicit priming and activation of the inflammasome complex, how the activated inflammasome complex contributes to cardiovascular pathophysiology and fibrosis progression, and the molecular mechanisms involved from various cell culture and animal model studies that have utilised genetic deletion or pharmacological inhibition of specific components of the inflammasome. Finally, it outlines currently known and previously unrecognised cardiovascular receptors that may be pharmacologically targeted to ablate the contribution of the NLRP3 inflammasome to cardiovascular diseases characterised by fibrosis, by compounds that may be developed as effective adjunct therapies to current standard of care medication." @default.
• W3007109404 created "2020-03-06" @default.
• W3007109404 creator A5007345014 @default.
• W3007109404 creator A5029379615 @default.
• W3007109404 creator A5067703598 @default.
• W3007109404 creator A5068611898 @default.
• W3007109404 creator A5069893866 @default.
• W3007109404 creator A5091898169 @default.
• W3007109404 date "2020-05-01" @default.
• W3007109404 modified "2023-10-10" @default.
• W3007109404 title "Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis" @default.
• W3007109404 cites W1497243630 @default.
• W3007109404 cites W1511076563 @default.
• W3007109404 cites W1528562310 @default.
• W3007109404 cites W1528708838 @default.
• W3007109404 cites W1530472930 @default.
• W3007109404 cites W1540726332 @default.
• W3007109404 cites W1558140044 @default.
• W3007109404 cites W1566050849 @default.
• W3007109404 cites W1606333366 @default.
• W3007109404 cites W1608457896 @default.
• W3007109404 cites W1790743604 @default.
• W3007109404 cites W1849785625 @default.
• W3007109404 cites W1866413456 @default.
• W3007109404 cites W1874970247 @default.
• W3007109404 cites W1886716828 @default.
• W3007109404 cites W1900592574 @default.
• W3007109404 cites W1940453590 @default.
• W3007109404 cites W1948364467 @default.
• W3007109404 cites W1949832432 @default.
• W3007109404 cites W1951267756 @default.
• W3007109404 cites W1964751888 @default.
• W3007109404 cites W1965371986 @default.
• W3007109404 cites W1965524726 @default.
• W3007109404 cites W1965599418 @default.
• W3007109404 cites W1965618734 @default.
• W3007109404 cites W1967272371 @default.
• W3007109404 cites W1967366037 @default.
• W3007109404 cites W1967675172 @default.
• W3007109404 cites W1968903007 @default.
• W3007109404 cites W1972749969 @default.
• W3007109404 cites W1979582673 @default.
• W3007109404 cites W1979934328 @default.
• W3007109404 cites W1980046478 @default.
• W3007109404 cites W1980325398 @default.
• W3007109404 cites W1983102904 @default.
• W3007109404 cites W1984002529 @default.
• W3007109404 cites W1985236576 @default.
• W3007109404 cites W1985532214 @default.
• W3007109404 cites W1985538633 @default.
• W3007109404 cites W1986233023 @default.
• W3007109404 cites W1990374465 @default.
• W3007109404 cites W1990635289 @default.
• W3007109404 cites W1991611246 @default.
• W3007109404 cites W1993865500 @default.
• W3007109404 cites W1994758980 @default.
• W3007109404 cites W1995158939 @default.
• W3007109404 cites W1995253472 @default.
• W3007109404 cites W1995848477 @default.
• W3007109404 cites W1996507370 @default.
• W3007109404 cites W1997762393 @default.
• W3007109404 cites W1999644843 @default.
• W3007109404 cites W2000084615 @default.
• W3007109404 cites W2001717879 @default.
• W3007109404 cites W2003206167 @default.
• W3007109404 cites W2005410446 @default.
• W3007109404 cites W2006452753 @default.
• W3007109404 cites W2008074040 @default.
• W3007109404 cites W2008835388 @default.
• W3007109404 cites W2009523990 @default.
• W3007109404 cites W2010216650 @default.
• W3007109404 cites W2010431766 @default.
• W3007109404 cites W2011813460 @default.
• W3007109404 cites W2012927900 @default.
• W3007109404 cites W2014812641 @default.
• W3007109404 cites W2016193552 @default.
• W3007109404 cites W2017946623 @default.
• W3007109404 cites W2018492901 @default.
• W3007109404 cites W2018792951 @default.
• W3007109404 cites W2020765596 @default.
• W3007109404 cites W2024003051 @default.
• W3007109404 cites W2024690705 @default.
• W3007109404 cites W2026051436 @default.
• W3007109404 cites W2026470245 @default.
• W3007109404 cites W2027132059 @default.
• W3007109404 cites W2028600070 @default.
• W3007109404 cites W2028834733 @default.
• W3007109404 cites W2031759320 @default.
• W3007109404 cites W2032049229 @default.
• W3007109404 cites W2032576629 @default.
• W3007109404 cites W2034315625 @default.
• W3007109404 cites W2036782018 @default.
• W3007109404 cites W2039601697 @default.
• W3007109404 cites W2044590154 @default.
• W3007109404 cites W2045142779 @default.
• W3007109404 cites W2045474881 @default.
• W3007109404 cites W2046355810 @default.
• W3007109404 cites W2047592317 @default.

• next