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- W3007116508 endingPage "1252" @default.
- W3007116508 startingPage "1241" @default.
- W3007116508 abstract "Type 1 diabetes mellitus (T1DM) is a chronic, autoimmune disease that is characterized by total absence of insulin production. Hypertension is a common comorbidity in T1DM with complex pathophysiology, while it is also a well-recognized risk factor for the development of cardiovascular disease (CVD), as well as other microvascular diabetic complications.The purpose of this review is to present the current definitions, epidemiological data and prevalence rates of hypertension in T1DM, as well as to describe current therapeutic options.Hypertension affects around a third of the type 1 diabetic population, with higher prevalence rates in older individuals with longer disease duration. Although hypertension affects a substantial proportion of T1DM individuals, blood pressure control rates are disappointingly low. Alongside lifestyle modification, antihypertensive treatment should be initiated in those with blood pressure above 140/90 mmHg, with a systolic blood pressure target of 130 mmHg and lower, if tolerated. In those with established CVD or diabetic nephropathy, systolic blood pressure targets below 130 mmHg should be pursued. Initial pharmacotherapy should consist of a renin-angiotensin-aldosterone system inhibitor. There is an urgent need for good quality data regarding proper antihypertensive treatment initiation, optimal BP targets and optimal antihypertensive treatment for better clinical outcomes." @default.
- W3007116508 created "2020-03-06" @default.
- W3007116508 creator A5037285876 @default.
- W3007116508 creator A5077361613 @default.
- W3007116508 creator A5080425950 @default.
- W3007116508 creator A5080657717 @default.
- W3007116508 creator A5081319316 @default.
- W3007116508 creator A5091008679 @default.
- W3007116508 date "2020-02-17" @default.
- W3007116508 modified "2023-10-18" @default.
- W3007116508 title "Treatment strategies for hypertension in patients with type 1 diabetes" @default.
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