Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007124350> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3007124350 abstract "BACKGROUND Rituximab is a genetically engineered chimeric (murine-human) monoclonal antibody (mAb) directed against CD20 antigen on the surface of B cells. Commonly reported adverse effects are chills and fevers, which are usually associated with the first infusion. Recent studies have shown an association between rituximab use and low immunoglobulin (Ig) level due to a reduction in plasma cell precursors, which leads to an increased risk of infections with the use of rituximab. CASE REPORT We present a case of hypogammaglobulinemia associated with rituximab use in a patient with Granulomatosis with Polyangiitis (GPA). A 59-year-old woman presented with shortness of breath. After an extensive workup, she was diagnosed with GPA. She received rituximab for the induction of remission. Laboratory workup, which was done five days after she received the second rituximab dose, showed IgG and IgM levels below the level of normal. One month after her second dose of rituximab, she presented to the Medical Intensive Care Unit as a transfer from an outside facility intubated and sedated due to acute respiratory failure secondary to septic shock with E. coli bacteremia. The patient died on admission despite aggressive management, including the ACLS protocol. CONCLUSIONS Rituximab is an effective medication in the management of ANCA-associated vasculitis. Obtaining an immunoglobulin level at baseline and before each rituximab cycle is of great clinical importance and helps guide physicians in prescribing B cell-targeted therapy." @default.
- W3007124350 created "2020-03-06" @default.
- W3007124350 creator A5004353372 @default.
- W3007124350 creator A5005367701 @default.
- W3007124350 creator A5056985121 @default.
- W3007124350 creator A5084943193 @default.
- W3007124350 date "2020-02-24" @default.
- W3007124350 modified "2023-09-23" @default.
- W3007124350 title "Rituximab Use and Hypogammaglobulinemia" @default.
- W3007124350 cites W2030437282 @default.
- W3007124350 cites W2063340779 @default.
- W3007124350 cites W2070412267 @default.
- W3007124350 cites W2133803400 @default.
- W3007124350 cites W2147749143 @default.
- W3007124350 cites W2163003110 @default.
- W3007124350 cites W2163488378 @default.
- W3007124350 cites W2227274114 @default.
- W3007124350 cites W2607034987 @default.
- W3007124350 cites W2921264466 @default.
- W3007124350 cites W2947252334 @default.
- W3007124350 doi "https://doi.org/10.12659/ajcr.920681" @default.
- W3007124350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7171369" @default.
- W3007124350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32269210" @default.
- W3007124350 hasPublicationYear "2020" @default.
- W3007124350 type Work @default.
- W3007124350 sameAs 3007124350 @default.
- W3007124350 citedByCount "1" @default.
- W3007124350 countsByYear W30071243502020 @default.
- W3007124350 crossrefType "journal-article" @default.
- W3007124350 hasAuthorship W3007124350A5004353372 @default.
- W3007124350 hasAuthorship W3007124350A5005367701 @default.
- W3007124350 hasAuthorship W3007124350A5056985121 @default.
- W3007124350 hasAuthorship W3007124350A5084943193 @default.
- W3007124350 hasBestOaLocation W30071243502 @default.
- W3007124350 hasConcept C126322002 @default.
- W3007124350 hasConcept C159654299 @default.
- W3007124350 hasConcept C18031839 @default.
- W3007124350 hasConcept C197934379 @default.
- W3007124350 hasConcept C203014093 @default.
- W3007124350 hasConcept C2776015282 @default.
- W3007124350 hasConcept C2777628635 @default.
- W3007124350 hasConcept C2777805810 @default.
- W3007124350 hasConcept C2778384902 @default.
- W3007124350 hasConcept C2778594517 @default.
- W3007124350 hasConcept C2779134260 @default.
- W3007124350 hasConcept C2779443120 @default.
- W3007124350 hasConcept C2780653079 @default.
- W3007124350 hasConcept C2781229154 @default.
- W3007124350 hasConcept C501593827 @default.
- W3007124350 hasConcept C71924100 @default.
- W3007124350 hasConcept C86803240 @default.
- W3007124350 hasConcept C89423630 @default.
- W3007124350 hasConceptScore W3007124350C126322002 @default.
- W3007124350 hasConceptScore W3007124350C159654299 @default.
- W3007124350 hasConceptScore W3007124350C18031839 @default.
- W3007124350 hasConceptScore W3007124350C197934379 @default.
- W3007124350 hasConceptScore W3007124350C203014093 @default.
- W3007124350 hasConceptScore W3007124350C2776015282 @default.
- W3007124350 hasConceptScore W3007124350C2777628635 @default.
- W3007124350 hasConceptScore W3007124350C2777805810 @default.
- W3007124350 hasConceptScore W3007124350C2778384902 @default.
- W3007124350 hasConceptScore W3007124350C2778594517 @default.
- W3007124350 hasConceptScore W3007124350C2779134260 @default.
- W3007124350 hasConceptScore W3007124350C2779443120 @default.
- W3007124350 hasConceptScore W3007124350C2780653079 @default.
- W3007124350 hasConceptScore W3007124350C2781229154 @default.
- W3007124350 hasConceptScore W3007124350C501593827 @default.
- W3007124350 hasConceptScore W3007124350C71924100 @default.
- W3007124350 hasConceptScore W3007124350C86803240 @default.
- W3007124350 hasConceptScore W3007124350C89423630 @default.
- W3007124350 hasLocation W30071243501 @default.
- W3007124350 hasLocation W30071243502 @default.
- W3007124350 hasLocation W30071243503 @default.
- W3007124350 hasLocation W30071243504 @default.
- W3007124350 hasOpenAccess W3007124350 @default.
- W3007124350 hasPrimaryLocation W30071243501 @default.
- W3007124350 hasRelatedWork W2019981736 @default.
- W3007124350 hasRelatedWork W2028217419 @default.
- W3007124350 hasRelatedWork W2044994497 @default.
- W3007124350 hasRelatedWork W2141478510 @default.
- W3007124350 hasRelatedWork W2227274114 @default.
- W3007124350 hasRelatedWork W2405771326 @default.
- W3007124350 hasRelatedWork W2409398768 @default.
- W3007124350 hasRelatedWork W2409771798 @default.
- W3007124350 hasRelatedWork W2986935334 @default.
- W3007124350 hasRelatedWork W2997611592 @default.
- W3007124350 isParatext "false" @default.
- W3007124350 isRetracted "false" @default.
- W3007124350 magId "3007124350" @default.
- W3007124350 workType "article" @default.