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• W3007133217 endingPage "129581" @default.
• W3007133217 startingPage "129581" @default.
• W3007133217 abstract "In Gram-negative bacteria, type Va and Vc autotransporters are proteins that contain both a secreted virulence factor (the “passenger” domain) and a β-barrel that aids its export. While it is known that the folding and insertion of the β-barrel domain utilize the β-barrel assembly machinery (BAM) complex, how the passenger domain is secreted and folded across the membrane remains to be determined. The hairpin model states that passenger domain secretion occurs independently through the fully-formed and membrane-inserted β-barrel domain via a hairpin folding intermediate. In contrast, the BamA-assisted model states that the passenger domain is secreted through a hybrid of BamA, the essential subunit of the BAM complex, and the β-barrel domain of the autotransporter. To ascertain the models' plausibility, we have used molecular dynamics to simulate passenger domain secretion for two autotransporters, EspP and YadA. We observed that each protein's β-barrel is unable to accommodate the secreting passenger domain in a hairpin configuration without major structural distortions. Additionally, the force required for secretion through EspP's β-barrel is more than that through the BamA β-barrel. Secretion of autotransporters most likely occurs through an incompletely formed β-barrel domain of the autotransporter in conjunction with BamA. Secretion of virulence factors is a process used by practically all pathogenic Gram-negative bacteria. Understanding this process is a necessary step towards limiting their infectious capacity. • Autotransporters (ATs) are bacterial outer-membrane proteins that secrete their own virulence factors. • Simulations reveal that the AT beta-barrel alone is insufficient to support secretion on its own. • However, BamA, which has a larger beta-barrel than ATs, may aid secretion, possibly in conjunction with the AT." @default.
• W3007133217 created "2020-03-06" @default.
• W3007133217 creator A5017648021 @default.
• W3007133217 creator A5030083039 @default.
• W3007133217 creator A5060500326 @default.
• W3007133217 creator A5079211725 @default.
• W3007133217 creator A5080510232 @default.
• W3007133217 creator A5083496847 @default.
• W3007133217 date "2020-07-01" @default.
• W3007133217 modified "2023-10-13" @default.
• W3007133217 title "BamA is required for autotransporter secretion" @default.
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• W3007133217 doi "https://doi.org/10.1016/j.bbagen.2020.129581" @default.
• W3007133217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7196024" @default.
• W3007133217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32114025" @default.
• W3007133217 hasPublicationYear "2020" @default.
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