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• W3007142803 abstract "Pancreatic cancer (PC) mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. Long non-coding RNAs (lncRNAs) are well known as a class of transcripts involved in cancer occurrence and progression. The process of epithelial to a mesenchymal (EMT) phenotype in tumor cell increases their migratory and invasive properties, resulting in facilitating metastasis. Here, we reanalyzed RNA-seq data from the TCGA PC database and identified that ENS0254041.1 increasingly expressed in samples with elevated EMT signature score. Then, the evaluated expression and prognostic significance of ENS0254041.1 were verified in our cohort. Meanwhile, multivariate analysis suggested that ENS0254041.1 was independent factors for predicting the prognosis of PC, apart from advanced stage (III/IV). Moreover, functional assay revealed that knock down of ENS0254041.1 significantly decreased proliferation, invasion and chemoresistance of PC cells (SW1990 and BxPC-3), while overexpression of ENS0254041.1 in PC cells (Panc-1) resulted in the opposite effects. Western blot showed that knockdown of ENS0254041.1 expression in PC cells caused a significant downregulation of vimentin, Snail and SOX4, and upregulation of E-cadherin; also, ENS0254041.1 overexpression in PC cells resulted in opposite effects. In conclusion, these findings indicated that ENS0254041.1 promotes PC progression, and might provide a potential biomarker for predicting the prognosis of PC." @default.
• W3007142803 created "2020-03-06" @default.
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• W3007142803 date "2020-02-23" @default.
• W3007142803 modified "2023-09-25" @default.
• W3007142803 title "The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma" @default.
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• W3007142803 doi "https://doi.org/10.18632/aging.102835" @default.
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