Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007206573> ?p ?o ?g. }
- W3007206573 abstract "Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) is overexpressed in human central nervous system malignancies, including medulloblastoma, a common pediatric brain cancer. While global knockout does not overtly affect mouse development, genetic deletion of CLIC1 suppresses medulloblastoma growth in xenograft and genetically engineered mouse models. Mechanistically, CLIC1 enriches to the plasma membrane during mitosis and cooperates with potassium channel EAG2 at lipid rafts to regulate cell volume homeostasis. CLIC1 deficiency is associated with elevation of cell/nuclear volume ratio, uncoupling between RNA biosynthesis and cell size increase, and activation of the p38 MAPK pathway that suppresses proliferation. Concurrent knockdown of CLIC1/EAG2 and their evolutionarily conserved channels synergistically suppressed the growth of human medulloblastoma cells and Drosophila melanogaster brain tumors, respectively. These findings establish CLIC1 as a molecular dependency in rapidly dividing medulloblastoma cells, provide insights into the mechanism by which CLIC1 regulates tumorigenesis, and reveal that targeting CLIC1 and its functionally cooperative potassium channel is a disease-intervention strategy." @default.
- W3007206573 created "2020-03-06" @default.
- W3007206573 creator A5004068427 @default.
- W3007206573 creator A5006710389 @default.
- W3007206573 creator A5009041202 @default.
- W3007206573 creator A5022310517 @default.
- W3007206573 creator A5026129549 @default.
- W3007206573 creator A5028891523 @default.
- W3007206573 creator A5035537607 @default.
- W3007206573 creator A5040124749 @default.
- W3007206573 creator A5040595262 @default.
- W3007206573 creator A5045246728 @default.
- W3007206573 creator A5049451190 @default.
- W3007206573 creator A5050638862 @default.
- W3007206573 creator A5053512215 @default.
- W3007206573 creator A5056728450 @default.
- W3007206573 creator A5060323164 @default.
- W3007206573 creator A5062508649 @default.
- W3007206573 creator A5065062425 @default.
- W3007206573 creator A5065881412 @default.
- W3007206573 creator A5072615424 @default.
- W3007206573 creator A5073054729 @default.
- W3007206573 creator A5078479753 @default.
- W3007206573 creator A5089743346 @default.
- W3007206573 date "2020-02-25" @default.
- W3007206573 modified "2023-10-06" @default.
- W3007206573 title "Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth" @default.
- W3007206573 cites W1953797643 @default.
- W3007206573 cites W1965232742 @default.
- W3007206573 cites W1966702895 @default.
- W3007206573 cites W1972207998 @default.
- W3007206573 cites W1974798136 @default.
- W3007206573 cites W1982789849 @default.
- W3007206573 cites W1983341583 @default.
- W3007206573 cites W1985596675 @default.
- W3007206573 cites W2021218886 @default.
- W3007206573 cites W2025436502 @default.
- W3007206573 cites W2025700341 @default.
- W3007206573 cites W2031092352 @default.
- W3007206573 cites W2032484783 @default.
- W3007206573 cites W2047628400 @default.
- W3007206573 cites W2049973503 @default.
- W3007206573 cites W2057322232 @default.
- W3007206573 cites W2059697575 @default.
- W3007206573 cites W2065387800 @default.
- W3007206573 cites W2066868268 @default.
- W3007206573 cites W2078395247 @default.
- W3007206573 cites W2079593971 @default.
- W3007206573 cites W2084217771 @default.
- W3007206573 cites W2084607178 @default.
- W3007206573 cites W2100300374 @default.
- W3007206573 cites W2107098864 @default.
- W3007206573 cites W2108643161 @default.
- W3007206573 cites W2121017846 @default.
- W3007206573 cites W2122180401 @default.
- W3007206573 cites W2127643721 @default.
- W3007206573 cites W2130264065 @default.
- W3007206573 cites W2142822714 @default.
- W3007206573 cites W2156139362 @default.
- W3007206573 cites W2163073962 @default.
- W3007206573 cites W2166084756 @default.
- W3007206573 cites W2170174897 @default.
- W3007206573 cites W2190272052 @default.
- W3007206573 cites W2261407434 @default.
- W3007206573 cites W2279473742 @default.
- W3007206573 cites W2300908044 @default.
- W3007206573 cites W2343540608 @default.
- W3007206573 cites W2499716284 @default.
- W3007206573 cites W2526241242 @default.
- W3007206573 cites W2594586514 @default.
- W3007206573 cites W2626440326 @default.
- W3007206573 cites W2896808622 @default.
- W3007206573 cites W2911928150 @default.
- W3007206573 cites W581666381 @default.
- W3007206573 doi "https://doi.org/10.1084/jem.20190971" @default.
- W3007206573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7201926" @default.
- W3007206573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32097463" @default.
- W3007206573 hasPublicationYear "2020" @default.
- W3007206573 type Work @default.
- W3007206573 sameAs 3007206573 @default.
- W3007206573 citedByCount "22" @default.
- W3007206573 countsByYear W30072065732020 @default.
- W3007206573 countsByYear W30072065732021 @default.
- W3007206573 countsByYear W30072065732022 @default.
- W3007206573 countsByYear W30072065732023 @default.
- W3007206573 crossrefType "journal-article" @default.
- W3007206573 hasAuthorship W3007206573A5004068427 @default.
- W3007206573 hasAuthorship W3007206573A5006710389 @default.
- W3007206573 hasAuthorship W3007206573A5009041202 @default.
- W3007206573 hasAuthorship W3007206573A5022310517 @default.
- W3007206573 hasAuthorship W3007206573A5026129549 @default.
- W3007206573 hasAuthorship W3007206573A5028891523 @default.
- W3007206573 hasAuthorship W3007206573A5035537607 @default.
- W3007206573 hasAuthorship W3007206573A5040124749 @default.
- W3007206573 hasAuthorship W3007206573A5040595262 @default.
- W3007206573 hasAuthorship W3007206573A5045246728 @default.
- W3007206573 hasAuthorship W3007206573A5049451190 @default.
- W3007206573 hasAuthorship W3007206573A5050638862 @default.
- W3007206573 hasAuthorship W3007206573A5053512215 @default.
- W3007206573 hasAuthorship W3007206573A5056728450 @default.