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- W3007232760 abstract "Multidrug-resistant (MDR) tuberculosis remains a major threat to global public health security, despite advances that include new tuberculosis drugs, treatment regimens, and rapid diagnostics. In 2018, there were an estimated half a million new cases of rifampicin-resistant tuberculosis; 78% of these cases had MDR tuberculosis. 1 WHOGlobal tuberculosis report. https://www.who.int/tb/publications/global_report/en/Date: 2019 Date accessed: January 31, 2020 Google Scholar Current WHO treatment recommendations for MDR tuberculosis propose a combination of anti-Mycobacterium tuberculosis drugs, most of which have serious side-effects and have to be taken for 6–18 months. 1 WHOGlobal tuberculosis report. https://www.who.int/tb/publications/global_report/en/Date: 2019 Date accessed: January 31, 2020 Google Scholar The risk of M tuberculosis developing resistance to these agents is a continuous problem. It has taken over 25 years to develop three new tuberculosis drugs—delamanid, bedaquiline, and pretomanid—which have improved the outcomes of treatment regimens for MDR tuberculosis. However, resistance to bedaquiline has already been documented" @default.
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- W3007232760 date "2020-04-01" @default.
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- W3007232760 title "Host-directed therapies and holistic care for tuberculosis" @default.
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- W3007232760 doi "https://doi.org/10.1016/s2213-2600(20)30078-3" @default.
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