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• W3007261124 abstract "The scope of the acid-mediated 3-component synthesis of thiadiazines was investigated. A selective functionalization of the six-membered heterocyclic core structure was accomplished by sequential alkylations, saponifications, and coupling reactions. Several new analogs of a dihydropyrimidinone Hsp70 chaperone agonist, MAL1-271, showed promising activity in a cell based model of Huntington’s disease." @default.
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• W3007261124 date "2020-02-20" @default.
• W3007261124 modified "2023-10-12" @default.
• W3007261124 title "Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington’s Disease" @default.
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• W3007261124 doi "https://doi.org/10.1021/acsmedchemlett.0c00018" @default.
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