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- W3007276038 abstract "Metallothioneins (MTs) are frequently observed in many different cancers including breast cancer (BC). MT2A is the most expressed isoform in the breast cells. This case-control analysis, consisting of 60 patients with BC and 40 healthy controls, measures the comparative expression of blood Metallothionein-2A mRNA, overall antioxidant and oxidant status with malignant breast tumours and their relation to the various grades of breast cancer. It was assessed by real-time polymerase chain reaction (RT-PCR), serum total oxidant status (TOS), total antioxidant status (TAS) were measured calorimetrically. OSI (oxidative stress index) was calculated. Breast cancer cases showed significantly higher MT2A relative expression when compared to the control group (upregulation). Breast cancer cases showed significantly higher TOS, OSI, and lower TAS concentrations when compared to the control group. The MT2-A mRNA expression is positively correlated with histological grades and stages of breast cancer. Blood Metallothionein- 2A relative expression and oxidant status may have a prognostic value in breast cancer patients." @default.
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- W3007276038 date "2020-06-01" @default.
- W3007276038 modified "2023-09-27" @default.
- W3007276038 title "Study of metallothionein-2A mRNA relative expression and oxidant status in females with breast cancer" @default.
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- W3007276038 doi "https://doi.org/10.1016/j.mgene.2020.100678" @default.
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