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- W3007317167 abstract "This study aimed to identify the genes that cause biochemical recurrence (BCR) following radical prostatectomy (RP) in men with localized prostate cancer.A two-stage genetic association study of 19 single-nucleotide polymorphisms in 11 key cell cycle regulation genes was carried out. BCR-free survival after RP was evaluated in a discovery cohort of 458 patients with prostate cancer, and replication was investigated in another cohort of 185 patients.A consistent association was found between BCR and rs2290291 (discovery: p=0.008; replication: p=0.029). rs2290291 is located in the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), and was predicted to possess a regulatory function that affected YWHAZ expression. Furthermore, YWHAZ expression was frequently up-regulated in advanced tumours, and associated with poorer survival in patients with prostate cancer.YWHAZ rs2290291 was found to be associated with BCR. YWHAZ may function as a putative oncogene during prostate cancer progression." @default.
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- W3007317167 date "2020-01-01" @default.
- W3007317167 modified "2023-10-14" @default.
- W3007317167 title "Genetic Association Analysis of Cell Cycle Regulators Reveals <i>YWHAZ</i> Has Prognostic Significance in Prostate Cancer" @default.
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- W3007317167 doi "https://doi.org/10.21873/cgp.20181" @default.
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