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- W3007329049 abstract "Basal cell carcinoma (BCC) is the single commonest human malignancy. Histologically, BCC is classified into one of several subtypes based on the growth pattern, a feature that correlates with risk of aggressive behaviour. Metastasis is exceptionally rare and portends a poor prognosis. Although the genome of BCC has been fully characterised, little is known about genomic events associated with metastatic potential. We sought to identify clinicopathologic and molecular features associated with an increased risk of metastasis in BCC. Cases were identified from a search of our institutional database. The pathology of each primary tumour and corresponding metastasis was reviewed, followed by DNA extraction and whole-exome sequencing. The detected molecular alterations were compared between the primary tumour and the corresponding metastasis. The findings were compared to publicly available genomic data. 9 patients were identified, with matched primary tumour tissue available in 7 cases. 6 cases originated in the head and neck. Sites of metastasis were local lymph nodes (7/9) and lung (2/9). Most primary tumours were at least partially infiltrative (4/7) or morphoeic (2/7). Results of genomic analyses will be presented and will provide insights into molecular events that may serve as biomarkers for the rare complication of metastasis in BCC." @default.
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- W3007329049 date "2020-02-01" @default.
- W3007329049 modified "2023-09-26" @default.
- W3007329049 title "Genomic alterations in metastatic basal cell carcinoma" @default.
- W3007329049 doi "https://doi.org/10.1016/j.pathol.2020.01.204" @default.
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