Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007332834> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3007332834 endingPage "AB223" @default.
- W3007332834 startingPage "AB223" @default.
- W3007332834 abstract "We have established a clinical research system for allergic disease “MINERVA” that integrates the latest information technology and proteomics technology to realize an efficient implementation system for food allergic research. In this study, we used the system for shrimp allergy, identified and verified allergen components, and analyzed the IgE epitopes. Subjects were 29 cases (average age: 37 yrs, sex: 9 males, 20 females) registered in MINERVA, who had immediate allergic symptoms after taking shrimp and were positive for a skin prick test and / or specific IgE test for shrimp. Identification of allergen components was performed by 2-D western blot (2D-WB) using the extracted shrimp protein and verified by enzyme-linked immunosorbent assay using the recombinant proteins synthesized in E. coli. To identify IgE epitopes, we evaluated the binding of IgE to peptides derived from these proteins. Eleven proteins were identified as allergen components, including tropomyosin registered in WHO / IUIS, and it was found that there were many cases sensitized to myosin heavy chain. Various IgE epitopes were identified for each protein. In particular, it was confirmed that the myosin heavy chain contains many IgE epitopes. In shrimp allergy, several new antigens and the epitopes were identified, and myosin heavy chain was found to be a particularly important allergen component. The MINERVA system enables efficient clinical research, and immunoproteomic technology is a powerful and sensitive approach for comprehensive identification of food allergens." @default.
- W3007332834 created "2020-03-06" @default.
- W3007332834 creator A5021048743 @default.
- W3007332834 creator A5056664497 @default.
- W3007332834 creator A5060967666 @default.
- W3007332834 creator A5063087094 @default.
- W3007332834 creator A5068198210 @default.
- W3007332834 creator A5078819665 @default.
- W3007332834 creator A5079318660 @default.
- W3007332834 creator A5079841734 @default.
- W3007332834 creator A5082791998 @default.
- W3007332834 creator A5088831645 @default.
- W3007332834 date "2020-02-01" @default.
- W3007332834 modified "2023-09-27" @default.
- W3007332834 title "Antigen analysis of shrimp allergy using clinical research system for allergic disease “MINERVA”" @default.
- W3007332834 doi "https://doi.org/10.1016/j.jaci.2019.12.177" @default.
- W3007332834 hasPublicationYear "2020" @default.
- W3007332834 type Work @default.
- W3007332834 sameAs 3007332834 @default.
- W3007332834 citedByCount "0" @default.
- W3007332834 crossrefType "journal-article" @default.
- W3007332834 hasAuthorship W3007332834A5021048743 @default.
- W3007332834 hasAuthorship W3007332834A5056664497 @default.
- W3007332834 hasAuthorship W3007332834A5060967666 @default.
- W3007332834 hasAuthorship W3007332834A5063087094 @default.
- W3007332834 hasAuthorship W3007332834A5068198210 @default.
- W3007332834 hasAuthorship W3007332834A5078819665 @default.
- W3007332834 hasAuthorship W3007332834A5079318660 @default.
- W3007332834 hasAuthorship W3007332834A5079841734 @default.
- W3007332834 hasAuthorship W3007332834A5082791998 @default.
- W3007332834 hasAuthorship W3007332834A5088831645 @default.
- W3007332834 hasBestOaLocation W30073328341 @default.
- W3007332834 hasConcept C141105273 @default.
- W3007332834 hasConcept C147483822 @default.
- W3007332834 hasConcept C159654299 @default.
- W3007332834 hasConcept C195616568 @default.
- W3007332834 hasConcept C203014093 @default.
- W3007332834 hasConcept C207480886 @default.
- W3007332834 hasConcept C2776027960 @default.
- W3007332834 hasConcept C2776841996 @default.
- W3007332834 hasConcept C2780510475 @default.
- W3007332834 hasConcept C2781241564 @default.
- W3007332834 hasConcept C505870484 @default.
- W3007332834 hasConcept C55493867 @default.
- W3007332834 hasConcept C6997183 @default.
- W3007332834 hasConcept C71924100 @default.
- W3007332834 hasConcept C86803240 @default.
- W3007332834 hasConceptScore W3007332834C141105273 @default.
- W3007332834 hasConceptScore W3007332834C147483822 @default.
- W3007332834 hasConceptScore W3007332834C159654299 @default.
- W3007332834 hasConceptScore W3007332834C195616568 @default.
- W3007332834 hasConceptScore W3007332834C203014093 @default.
- W3007332834 hasConceptScore W3007332834C207480886 @default.
- W3007332834 hasConceptScore W3007332834C2776027960 @default.
- W3007332834 hasConceptScore W3007332834C2776841996 @default.
- W3007332834 hasConceptScore W3007332834C2780510475 @default.
- W3007332834 hasConceptScore W3007332834C2781241564 @default.
- W3007332834 hasConceptScore W3007332834C505870484 @default.
- W3007332834 hasConceptScore W3007332834C55493867 @default.
- W3007332834 hasConceptScore W3007332834C6997183 @default.
- W3007332834 hasConceptScore W3007332834C71924100 @default.
- W3007332834 hasConceptScore W3007332834C86803240 @default.
- W3007332834 hasIssue "2" @default.
- W3007332834 hasLocation W30073328341 @default.
- W3007332834 hasOpenAccess W3007332834 @default.
- W3007332834 hasPrimaryLocation W30073328341 @default.
- W3007332834 hasRelatedWork W1481873398 @default.
- W3007332834 hasRelatedWork W1497231282 @default.
- W3007332834 hasRelatedWork W1975126408 @default.
- W3007332834 hasRelatedWork W2077768935 @default.
- W3007332834 hasRelatedWork W2078716447 @default.
- W3007332834 hasRelatedWork W2094536032 @default.
- W3007332834 hasRelatedWork W2181899375 @default.
- W3007332834 hasRelatedWork W2606634057 @default.
- W3007332834 hasRelatedWork W2783630444 @default.
- W3007332834 hasRelatedWork W2980050534 @default.
- W3007332834 hasVolume "145" @default.
- W3007332834 isParatext "false" @default.
- W3007332834 isRetracted "false" @default.
- W3007332834 magId "3007332834" @default.
- W3007332834 workType "article" @default.