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• W3007355462 endingPage "172876" @default.
• W3007355462 startingPage "172876" @default.
• W3007355462 abstract "Abstract Clinical and preclinical studies have shown that the N-methyl- d -aspartate receptor antagonist ketamine exerts rapid and long-lasting antidepressant effects. Although ketamine metabolites might also have potential antidepressant properties, controversial results have been reported for (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) in particular, and there is little information regarding the effects of other ketamine metabolites. Here we aimed to compare the effects of (R)-norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK, and (2S,6S)-HNK in a mouse model of depression induced by chronic corticosterone (CORT) injection. None of the ketamine metabolites at doses up to 20 mg/kg showed antidepressant-like activity in naive male C57BL6/J mice. Chronic CORT treatment increased immobility in the forced swim test and caused anhedonic-like behaviors in the female encounter test. A single administration of (S)-NK and (2S,6S)-HNK dose-dependently reduced the enhanced immobility at 30 min after injection in chronic CORT-treated mice, while (R)-NK or (2R,6R)-HNK did not. Additionally, (S)-NK and (2S,6S)-HNK, but not (R)-NK or (2R,6R)-HNK, improved chronic CORT-induced anhedonia at 24 h after the injection. These results suggest that (S)-ketamine metabolites (S)-NK and (2S,6S)-HNK have potent acute and sustained antidepressant effects in rodents." @default.
• W3007355462 created "2020-03-06" @default.
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• W3007355462 date "2020-04-01" @default.
• W3007355462 modified "2023-10-14" @default.
• W3007355462 title "(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression" @default.
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• W3007355462 doi "https://doi.org/10.1016/j.pbb.2020.172876" @default.
• W3007355462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32088360" @default.
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