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- W3007369076 abstract "Air pollutants exacerbates chronic airway disease such as asthma and COPD. But underlying mechanism for airway diseases remains unresolved. The aim of study was to identify protein expression in human lung microvascular endothelial cells (HMVEC-L) exposed to TiO2 ultrafine particles (UPs). A proteomic approach using 2DE and matrix assisted laser desorption time-of-flight spectrometry (MALDI-TOF/TOF MS) on the peptide sequence was used to determine the different expression of proteins at 8hr and 24hr after treatment of TiO2 UPs 20 μM and 40 μM to HLMVEC-L. Treatment of HMVEC-L with TiO2 UPs 20 μM altered 10 protein spots. These proteins included calcium regulation, transport, cytoskeleton, and muscle contraction. At concentration of 40 μM altered 5 protein spots. These proteins included cytoskeleton, myosin regulation, action modulating, and GDP and GTP regulation. For validation immunohistochemical staining and Western blotting was perfomed on lung tissues from UPs exposed mice. Profilin-1 and Cofilin-1 were expressed in endothelium, epithelium, and inflammatory cells and decreased in lung tissues of UPs exposed mice compared with sham treated mice. These results indicate that some of proteins may be an important role for airway disease caused by TiO2 ultrafine particles exposure." @default.
- W3007369076 created "2020-03-06" @default.
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- W3007369076 date "2020-02-01" @default.
- W3007369076 modified "2023-09-24" @default.
- W3007369076 title "Ultrafine particles change profilin-1 and cofilin-1 in human lung microvascular endothelial cells" @default.
- W3007369076 doi "https://doi.org/10.1016/j.jaci.2019.12.505" @default.
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