FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007376355> ?p ?o ?g. }

• W3007376355 endingPage "453" @default.
• W3007376355 startingPage "442" @default.
• W3007376355 abstract "Abstract Rapamycin has been proven to effectively inhibit the activation of primordial follicles while cisplatin‐induced the loss of primordial follicles due to the over‐activation of the primordial follicle stockpile. Whether rapamycin could inhibit the loss of primordial follicles induced by cisplatin is still unknown. The ovaries of neonatal Sprague Dawley rats were cultured in vitro in different doses of rapamycin (0.08, 0.16, and 0.32 μg/ml) and cisplatin (0.1, 0.4, and 0.8 μg/ml). The immature BALB/c mice were administered cisplatin with or without rapamycin by intraperitoneal injection. Ovaries were collected to analyze the histomorphology, the messenger RNA (mRNA) expression of anti‐Mullerian hormone (AMH), growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15) and the expression of key proteins of mammalian target of rapamycin (mTOR) pathway. Growing follicle counts of ovaries cultured in vitro in the R0.16 and R0.32 groups were decreased and the ratio of growing to primordial follicles was also decreased in a dose‐dependent manner. In the C0.8 group, growing follicles were decreased compared with the other groups while the ratio was substantially increased in the C0.4 and C0.8 group. Co‐treatment attenuated primordial follicle loss and reduced the upregulated ratio induced by cisplatin. Ovarian follicle dynamics in vivo was consistent with the in vitro results. Primordial follicles counts were statistically increased and the ratio was reduced in the rapamycin group compared with the control group. Primordial follicle counts were dramatically reduced in the cisplatin group whereas co‐treatment with rapamycin slightly recovered its counts. There was no obvious difference in the number of growing follicles between the cisplatin group and other groups. The ratio was significantly increased in cisplatin‐treated mice whereas decreased in the co‐treatment group. The apoptosis rate of antral follicles in cisplatin‐treated mice was higher than the other groups while the apoptosis rate was decreased in the co‐treatment group in vivo. Compared with the control and rapamycin group, the mRNA expression of AMH, GDF9, and BMP15 were downregulated in the cisplatin group. The co‐treatment group recovered the mRNA expression of BMP15. In addition, the expression of key protein of mTOR pathway rpS6 and its phosphorylated forms were increased in the cisplatin‐treated group while co‐treatment decreased their expression. Rapamycin attenuated the loss of primordial follicles induced by cisplatin through the inhibitory effect of rapamycin on the mTOR pathway. These results suggest that rapamycin may be an effective drug for the protection of ovarian function during chemotherapy." @default.
• W3007376355 created "2020-03-06" @default.
• W3007376355 creator A5001844543 @default.
• W3007376355 creator A5007131600 @default.
• W3007376355 creator A5019594394 @default.
• W3007376355 creator A5026043474 @default.
• W3007376355 creator A5038388427 @default.
• W3007376355 creator A5073951267 @default.
• W3007376355 creator A5081615766 @default.
• W3007376355 creator A5082756511 @default.
• W3007376355 date "2020-02-28" @default.
• W3007376355 modified "2023-09-27" @default.
• W3007376355 title "Rapamycin preserves the primordial follicle pool during cisplatin treatment in vitro and in vivo" @default.
• W3007376355 cites W1521000392 @default.
• W3007376355 cites W1846142415 @default.
• W3007376355 cites W1965988269 @default.
• W3007376355 cites W1966407635 @default.
• W3007376355 cites W1987604182 @default.
• W3007376355 cites W2006384445 @default.
• W3007376355 cites W2008127541 @default.
• W3007376355 cites W2019880257 @default.
• W3007376355 cites W2020564193 @default.
• W3007376355 cites W2026125986 @default.
• W3007376355 cites W2037977021 @default.
• W3007376355 cites W2054544978 @default.
• W3007376355 cites W2072220114 @default.
• W3007376355 cites W2086638852 @default.
• W3007376355 cites W2102304076 @default.
• W3007376355 cites W2121903033 @default.
• W3007376355 cites W2124424992 @default.
• W3007376355 cites W2125824537 @default.
• W3007376355 cites W2131121054 @default.
• W3007376355 cites W2135215861 @default.
• W3007376355 cites W2136159364 @default.
• W3007376355 cites W2137108265 @default.
• W3007376355 cites W2142075003 @default.
• W3007376355 cites W2147066718 @default.
• W3007376355 cites W2153143103 @default.
• W3007376355 cites W2153789247 @default.
• W3007376355 cites W2158978121 @default.
• W3007376355 cites W2194205022 @default.
• W3007376355 cites W2195343755 @default.
• W3007376355 cites W2283355026 @default.
• W3007376355 cites W2321763390 @default.
• W3007376355 cites W2342117069 @default.
• W3007376355 cites W2416978086 @default.
• W3007376355 cites W2526146892 @default.
• W3007376355 cites W2529359491 @default.
• W3007376355 cites W2591650235 @default.
• W3007376355 cites W2593816418 @default.
• W3007376355 cites W2730615870 @default.
• W3007376355 cites W2747858758 @default.
• W3007376355 cites W2766251113 @default.
• W3007376355 cites W2774120612 @default.
• W3007376355 cites W2787630576 @default.
• W3007376355 cites W2788725020 @default.
• W3007376355 doi "https://doi.org/10.1002/mrd.23330" @default.
• W3007376355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32112509" @default.
• W3007376355 hasPublicationYear "2020" @default.
• W3007376355 type Work @default.
• W3007376355 sameAs 3007376355 @default.
• W3007376355 citedByCount "10" @default.
• W3007376355 countsByYear W30073763552020 @default.
• W3007376355 countsByYear W30073763552021 @default.
• W3007376355 countsByYear W30073763552022 @default.
• W3007376355 countsByYear W30073763552023 @default.
• W3007376355 crossrefType "journal-article" @default.
• W3007376355 hasAuthorship W3007376355A5001844543 @default.
• W3007376355 hasAuthorship W3007376355A5007131600 @default.
• W3007376355 hasAuthorship W3007376355A5019594394 @default.
• W3007376355 hasAuthorship W3007376355A5026043474 @default.
• W3007376355 hasAuthorship W3007376355A5038388427 @default.
• W3007376355 hasAuthorship W3007376355A5073951267 @default.
• W3007376355 hasAuthorship W3007376355A5081615766 @default.
• W3007376355 hasAuthorship W3007376355A5082756511 @default.
• W3007376355 hasConcept C102570824 @default.
• W3007376355 hasConcept C126322002 @default.
• W3007376355 hasConcept C134018914 @default.
• W3007376355 hasConcept C150903083 @default.
• W3007376355 hasConcept C16685009 @default.
• W3007376355 hasConcept C196843134 @default.
• W3007376355 hasConcept C202751555 @default.
• W3007376355 hasConcept C207001950 @default.
• W3007376355 hasConcept C2776694085 @default.
• W3007376355 hasConcept C2777216303 @default.
• W3007376355 hasConcept C2778239845 @default.
• W3007376355 hasConcept C2778324911 @default.
• W3007376355 hasConcept C2780536345 @default.
• W3007376355 hasConcept C54355233 @default.
• W3007376355 hasConcept C5512455 @default.
• W3007376355 hasConcept C55493867 @default.
• W3007376355 hasConcept C71924100 @default.
• W3007376355 hasConcept C86803240 @default.
• W3007376355 hasConcept C87073359 @default.
• W3007376355 hasConcept C95444343 @default.
• W3007376355 hasConceptScore W3007376355C102570824 @default.
• W3007376355 hasConceptScore W3007376355C126322002 @default.
• W3007376355 hasConceptScore W3007376355C134018914 @default.

• next