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- W3007402360 abstract "The traditional view of ventricular excitation and conduction is an all-or-nothing response mediated by a regenerative activation of the inward sodium channel, which gives rise to an essentially constant conduction velocity (CV). However, whereas there is no obvious biological need to tune-up ventricular conduction, the principal molecular components determining CV, such as sodium channels, inward-rectifier potassium channels, and gap junctional channels, are known targets of the stress protein kinases PKA and calcium/calmodulin dependent protein kinase II (CaMKII), and are thus regulatable by signal pathways converging on these kinases. In this mini-review we will expose deficiencies and controversies in our current understanding of how ventricular conduction is regulated by stress kinases, with a special focus on the chamber-specific dimension in this regulation. In particular, we will highlight an odd property of cardiac physiology: uniform CV in ventricles requires co-existence of mutually opposing gradients in cardiac excitability and stress kinase function. While the biological advantage of this peculiar feature remains obscure, it is important to recognize the clinical implications of this phenomenon pertinent to inherited or acquired conduction diseases and therapeutic interventions modulating activity of PKA or CaMKII." @default.
- W3007402360 created "2020-03-06" @default.
- W3007402360 creator A5039434057 @default.
- W3007402360 creator A5077326135 @default.
- W3007402360 date "2020-02-18" @default.
- W3007402360 modified "2023-10-09" @default.
- W3007402360 title "“Heart Oddity”: Intrinsically Reduced Excitability in the Right Ventricle Requires Compensation by Regionally Specific Stress Kinase Function" @default.
- W3007402360 cites W1603881488 @default.
- W3007402360 cites W1964152667 @default.
- W3007402360 cites W1965851946 @default.
- W3007402360 cites W1967011394 @default.
- W3007402360 cites W1970314318 @default.
- W3007402360 cites W1972747419 @default.
- W3007402360 cites W1973630895 @default.
- W3007402360 cites W1976471618 @default.
- W3007402360 cites W1976504173 @default.
- W3007402360 cites W1979325786 @default.
- W3007402360 cites W1985654484 @default.
- W3007402360 cites W1986189584 @default.
- W3007402360 cites W1987374065 @default.
- W3007402360 cites W1989679097 @default.
- W3007402360 cites W1991649249 @default.
- W3007402360 cites W1996829258 @default.
- W3007402360 cites W1999196432 @default.
- W3007402360 cites W2001387569 @default.
- W3007402360 cites W2003284163 @default.
- W3007402360 cites W2009512836 @default.
- W3007402360 cites W2011778484 @default.
- W3007402360 cites W2012455479 @default.
- W3007402360 cites W2012760372 @default.
- W3007402360 cites W2018340928 @default.
- W3007402360 cites W2018773000 @default.
- W3007402360 cites W2023541966 @default.
- W3007402360 cites W2025444835 @default.
- W3007402360 cites W2026296218 @default.
- W3007402360 cites W2030880839 @default.
- W3007402360 cites W2031422633 @default.
- W3007402360 cites W2032962887 @default.
- W3007402360 cites W2033940966 @default.
- W3007402360 cites W2036395998 @default.
- W3007402360 cites W2037458621 @default.
- W3007402360 cites W2042464784 @default.
- W3007402360 cites W2045353535 @default.
- W3007402360 cites W2046148503 @default.
- W3007402360 cites W2050297059 @default.
- W3007402360 cites W2053215679 @default.
- W3007402360 cites W2059118042 @default.
- W3007402360 cites W2064163649 @default.
- W3007402360 cites W2068401800 @default.
- W3007402360 cites W2068538433 @default.
- W3007402360 cites W2070249204 @default.
- W3007402360 cites W2070965152 @default.
- W3007402360 cites W2073636244 @default.
- W3007402360 cites W2077844789 @default.
- W3007402360 cites W2079974543 @default.
- W3007402360 cites W2083358058 @default.
- W3007402360 cites W2097041593 @default.
- W3007402360 cites W2100968549 @default.
- W3007402360 cites W2103099058 @default.
- W3007402360 cites W2105658413 @default.
- W3007402360 cites W2109249622 @default.
- W3007402360 cites W2111909802 @default.
- W3007402360 cites W2112798012 @default.
- W3007402360 cites W2113359250 @default.
- W3007402360 cites W2115475608 @default.
- W3007402360 cites W2116297568 @default.
- W3007402360 cites W2122001651 @default.
- W3007402360 cites W2122008653 @default.
- W3007402360 cites W2124536475 @default.
- W3007402360 cites W2125843035 @default.
- W3007402360 cites W2127426595 @default.
- W3007402360 cites W2132622900 @default.
- W3007402360 cites W2135011583 @default.
- W3007402360 cites W2135576636 @default.
- W3007402360 cites W2136071898 @default.
- W3007402360 cites W2136275196 @default.
- W3007402360 cites W2139772036 @default.
- W3007402360 cites W2140379282 @default.
- W3007402360 cites W2148465842 @default.
- W3007402360 cites W2151774110 @default.
- W3007402360 cites W2153869960 @default.
- W3007402360 cites W2156011765 @default.
- W3007402360 cites W2158885517 @default.
- W3007402360 cites W2159008270 @default.
- W3007402360 cites W2159774610 @default.
- W3007402360 cites W2160129731 @default.
- W3007402360 cites W2166703440 @default.
- W3007402360 cites W2168217298 @default.
- W3007402360 cites W2199599000 @default.
- W3007402360 cites W2261110057 @default.
- W3007402360 cites W2335583226 @default.
- W3007402360 cites W2401933974 @default.
- W3007402360 cites W2415570395 @default.
- W3007402360 cites W2461153427 @default.
- W3007402360 cites W2464776507 @default.
- W3007402360 cites W2474949016 @default.
- W3007402360 cites W2513660408 @default.
- W3007402360 cites W2574058399 @default.
- W3007402360 cites W2582675228 @default.
- W3007402360 cites W2616549176 @default.