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• W3007422034 abstract "Abstract Objective To verify earlier data in cadavers that in female subjects with OA meniscal coverage is associated with lowered bone mineral density of the underlying subchondral bone in the proximal tibia by investigating the local bone mineral density (BMD) distribution within the epiphysis. Methods BMD of the subchondral bone of the tibia was measured by QCT in 67 elderly females diagnosed with OA (Kellgren-Lawrence grades 2–3). The epiphysis was subdivided along the axis of the tibia into a subchondral-epiphyseal VOI covering the first 5-6 mm below the subchondral bone plate, a mid-epiphyseal VOI covering the adjacent 7–8 and a juxtaphyseal VOI of another 7-8 mm that bordered the growth plate. These VIOs were further divided into lateral and medial and then into anterior, mid and posterior sub-VOIs. Finally, all subVOIs were divided in one subVOI covered by the menisci (CM) and another not covered by the menisci (nCM). BMD ratios of these two subVOIs were compared. Results In the subchondral epiphysis BMD was significantly lower (Medial: mean BMDdiff = 125 mg/cm3, p 0.82; Lateral: mean BMDdiff = 7 mg/cm3, p=0.99) and was reversed in the juxtaphysis. With a few exceptions these BMD differences were independent of the lateral-medial and the anterior-mid-posterior position. BMD significantly (p 0.1) change with age. Conclusion In-vivo QCT measurements of the BMD distribution in the proximal tibia indicate a protective effect of the menisci in the subchondral bone close to the joint. This protective effect is age independent despite the overall age-related decrease of BMD." @default.
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• W3007422034 date "2020-05-01" @default.
• W3007422034 modified "2023-10-18" @default.
• W3007422034 title "Impact of meniscal coverage on subchondral bone mineral density of the proximal tibia in female subjects – A cross-sectional in vivo study using QCT" @default.
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• W3007422034 doi "https://doi.org/10.1016/j.bone.2020.115292" @default.
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