FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007444811> ?p ?o ?g. }

• W3007444811 abstract "Several small cross-sectional studies have investigated cerebrospinal fluid (CSF) flow dynamics in multiple sclerosis (MS) patients and have reported mixed results. Currently, there are no longitudinal studies that investigate CSF dynamics in MS patients.To determine longitudinal changes in CSF dynamics measured at the level of aqueduct of Sylvius (AoS) in MS patients and matched healthy controls (HCs).Forty (40) MS patients and 20 HCs underwent 3T MRI cine phase contrast imaging with velocity-encoded pulse-gated sequence at baseline and 5-year follow-up. For atrophy determination, MS patients underwent additional high-resolution 3D T1-weighted imaging. Measures of AoS cross-sectional area (CSA), average systolic and diastolic velocity peaks, maximal systolic and diastolic velocity peaks and average CSF flow rates were determined. Brain atrophy and ventricular CSF (vCSF) expansion rates were determined. Cross-sectional and longitudinal changes were derived by analysis of covariance (ANCOVA) and paired repeated tests. Confirmatory general linear models were also performed. False discovery rate (FDR)-corrected p-values lower than 0.05 were considered significant.The MS population demonstrated significant increase in maximal diastolic peak (from 7.23 to 7.86 cm/s, non-adjusted p = 0.037), diastolic peak flow rate (7.76 ml/min to 9.33 ml/min, non-adjusted p = 0.023) and AoS CSA (from 3.12 to 3.69 mm2, adjusted p = 0.001). The only differentiator between MS patients and HCs was the greater AoS CSA (3.58 mm2 vs. 2.57 mm2, age- and sex-adjusted ANCOVA, p = 0.045). The AoS CSA change was associated with vCSF expansion rate (age- and sex-adjusted Spearman's correlation r = 0.496, p = 0.019) and not with baseline nor change in maximal velocity. The expansion rate of the vCSF space explained an additional 23.8% of variance in change of AoS CSA variance when compared to age and sex alone (R2 = 0.273, t = 2.557, standardized β = 0.51, and p = 0.019).MS patients present with significant longitudinal AoS enlargement, potentially due to regional atrophy changes and ex-vacuo expansion of the aqueduct." @default.
• W3007444811 created "2020-03-06" @default.
• W3007444811 creator A5041234325 @default.
• W3007444811 creator A5049031620 @default.
• W3007444811 creator A5055648634 @default.
• W3007444811 creator A5063933812 @default.
• W3007444811 creator A5075596287 @default.
• W3007444811 creator A5079130521 @default.
• W3007444811 date "2020-01-31" @default.
• W3007444811 modified "2023-10-17" @default.
• W3007444811 title "Longitudinal analysis of cerebral aqueduct flow measures: multiple sclerosis flow changes driven by brain atrophy" @default.
• W3007444811 cites W1988934276 @default.
• W3007444811 cites W2006799395 @default.
• W3007444811 cites W2009479470 @default.
• W3007444811 cites W2028942474 @default.
• W3007444811 cites W2041100416 @default.
• W3007444811 cites W2050096761 @default.
• W3007444811 cites W2081214545 @default.
• W3007444811 cites W2082076152 @default.
• W3007444811 cites W2102649050 @default.
• W3007444811 cites W2112165124 @default.
• W3007444811 cites W2115974623 @default.
• W3007444811 cites W2118739997 @default.
• W3007444811 cites W2119294636 @default.
• W3007444811 cites W2121121826 @default.
• W3007444811 cites W2122545833 @default.
• W3007444811 cites W2124480842 @default.
• W3007444811 cites W2148241230 @default.
• W3007444811 cites W2195838284 @default.
• W3007444811 cites W2337612449 @default.
• W3007444811 cites W2508875112 @default.
• W3007444811 cites W2522857677 @default.
• W3007444811 cites W2604246556 @default.
• W3007444811 cites W2773526620 @default.
• W3007444811 cites W2775401041 @default.
• W3007444811 cites W2790959140 @default.
• W3007444811 cites W2800466130 @default.
• W3007444811 cites W2806729167 @default.
• W3007444811 cites W2884910421 @default.
• W3007444811 cites W2886710738 @default.
• W3007444811 cites W2901936354 @default.
• W3007444811 cites W2910173545 @default.
• W3007444811 cites W2912741352 @default.
• W3007444811 cites W2913146869 @default.
• W3007444811 cites W2936190535 @default.
• W3007444811 cites W2954134793 @default.
• W3007444811 cites W2955166746 @default.
• W3007444811 cites W2958164393 @default.
• W3007444811 doi "https://doi.org/10.1186/s12987-020-0172-3" @default.
• W3007444811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6993504" @default.
• W3007444811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32000809" @default.
• W3007444811 hasPublicationYear "2020" @default.
• W3007444811 type Work @default.
• W3007444811 sameAs 3007444811 @default.
• W3007444811 citedByCount "7" @default.
• W3007444811 countsByYear W30074448112021 @default.
• W3007444811 countsByYear W30074448112022 @default.
• W3007444811 crossrefType "journal-article" @default.
• W3007444811 hasAuthorship W3007444811A5041234325 @default.
• W3007444811 hasAuthorship W3007444811A5049031620 @default.
• W3007444811 hasAuthorship W3007444811A5055648634 @default.
• W3007444811 hasAuthorship W3007444811A5063933812 @default.
• W3007444811 hasAuthorship W3007444811A5075596287 @default.
• W3007444811 hasAuthorship W3007444811A5079130521 @default.
• W3007444811 hasBestOaLocation W30074448111 @default.
• W3007444811 hasConcept C102959455 @default.
• W3007444811 hasConcept C105795698 @default.
• W3007444811 hasConcept C118552586 @default.
• W3007444811 hasConcept C126322002 @default.
• W3007444811 hasConcept C126838900 @default.
• W3007444811 hasConcept C143409427 @default.
• W3007444811 hasConcept C164705383 @default.
• W3007444811 hasConcept C2776820357 @default.
• W3007444811 hasConcept C2779651940 @default.
• W3007444811 hasConcept C2780640218 @default.
• W3007444811 hasConcept C2781172350 @default.
• W3007444811 hasConcept C2908647359 @default.
• W3007444811 hasConcept C2989005 @default.
• W3007444811 hasConcept C33923547 @default.
• W3007444811 hasConcept C57900726 @default.
• W3007444811 hasConcept C71924100 @default.
• W3007444811 hasConcept C84393581 @default.
• W3007444811 hasConcept C99454951 @default.
• W3007444811 hasConceptScore W3007444811C102959455 @default.
• W3007444811 hasConceptScore W3007444811C105795698 @default.
• W3007444811 hasConceptScore W3007444811C118552586 @default.
• W3007444811 hasConceptScore W3007444811C126322002 @default.
• W3007444811 hasConceptScore W3007444811C126838900 @default.
• W3007444811 hasConceptScore W3007444811C143409427 @default.
• W3007444811 hasConceptScore W3007444811C164705383 @default.
• W3007444811 hasConceptScore W3007444811C2776820357 @default.
• W3007444811 hasConceptScore W3007444811C2779651940 @default.
• W3007444811 hasConceptScore W3007444811C2780640218 @default.
• W3007444811 hasConceptScore W3007444811C2781172350 @default.
• W3007444811 hasConceptScore W3007444811C2908647359 @default.
• W3007444811 hasConceptScore W3007444811C2989005 @default.
• W3007444811 hasConceptScore W3007444811C33923547 @default.
• W3007444811 hasConceptScore W3007444811C57900726 @default.
• W3007444811 hasConceptScore W3007444811C71924100 @default.
• W3007444811 hasConceptScore W3007444811C84393581 @default.

• next