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- W3007452506 abstract "Abstract A new series of tetrahydroquinoline derivatives having pyrazol and hydrazide moieties were synthesized for the purpose of anticancer cell line evaluation. Syntheses of these compounds were firstly achieved by one pot four reactions. The reaction of 3‐amino‐tetrahydro‐1 H ‐pyrazolo [3,4‐b]quinolin with aldehydes, indoline‐2,3‐dione derivatives to give 9a‐c , 11a‐c , and 13a,b , respectively. In similar manner for biological comparison, the reactions of compound 5 with the same aldehydes and indoline‐2,3‐dione derivatives to give 19a‐c and 20a‐c . The newly synthesized compounds were examined in vitro for their cytotoxic activity against HepG‐2 and A549 cancer cells. The compounds 11a‐c and 20a‐c showed promising activity as anticancer agents against HepG‐2 and A549 cancer cells." @default.
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- W3007452506 date "2020-02-24" @default.
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- W3007452506 title "Synthesis and in vitro anticancer activity of some novel tetrahydroquinoline derivatives bearing pyrazol and hydrazide moiety" @default.
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- W3007452506 doi "https://doi.org/10.1002/jhet.3930" @default.
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