FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007458722> ?p ?o ?g. }

• W3007458722 abstract "Abstract Deciphering the activity-conformation relationship of PTPase is of great interest to understand how PTPase activity is determined by its conformation. Here we studied the activity and conformational transitions of PTPase from thermus thermophilus HB27 in the presence of sodium dodecyl sulfate (SDS). Activity assays showed the inactivation of PTPase induced by SDS was in a concentration-dependent manner. Fluorescence and circular dichroism spectra suggested SDS induced significant conformational transitions of PTPase, which resulted in the inactivation of PTPase, and the changes of α-helical structure and tertiary structure of PTPase. Structural analysis revealed a number of hydrophobic and charged residues around the active sites of PTPase may be involved in the hydrophobic and ionic bonds interactions of PTPase and SDS, which are suggested to be the major driving force to result in PTPase inactivation and conformational transitions induced by SDS. Our results suggested the hydrophobic and charged residues around the active sites were essential for the activity and conformation of PTPase. Our study promotes a better understanding of the activity and conformation of PTPase." @default.
• W3007458722 created "2020-03-06" @default.
• W3007458722 creator A5018126677 @default.
• W3007458722 creator A5023790849 @default.
• W3007458722 creator A5062469929 @default.
• W3007458722 date "2020-02-21" @default.
• W3007458722 modified "2023-10-12" @default.
• W3007458722 title "Effects of SDS on the activity and conformation of protein tyrosine phosphatase from thermus thermophilus HB27" @default.
• W3007458722 cites W1575456360 @default.
• W3007458722 cites W1578364075 @default.
• W3007458722 cites W1833680771 @default.
• W3007458722 cites W1964504843 @default.
• W3007458722 cites W1968319393 @default.
• W3007458722 cites W1969918683 @default.
• W3007458722 cites W1973087087 @default.
• W3007458722 cites W1974824041 @default.
• W3007458722 cites W1974913827 @default.
• W3007458722 cites W1975856283 @default.
• W3007458722 cites W1977802438 @default.
• W3007458722 cites W1980192669 @default.
• W3007458722 cites W1982074157 @default.
• W3007458722 cites W1983484838 @default.
• W3007458722 cites W1989899886 @default.
• W3007458722 cites W1990738958 @default.
• W3007458722 cites W1993737840 @default.
• W3007458722 cites W1996088244 @default.
• W3007458722 cites W1996583046 @default.
• W3007458722 cites W1997094739 @default.
• W3007458722 cites W2002271182 @default.
• W3007458722 cites W2005358949 @default.
• W3007458722 cites W2012973406 @default.
• W3007458722 cites W2034112681 @default.
• W3007458722 cites W2039852907 @default.
• W3007458722 cites W2042629507 @default.
• W3007458722 cites W2044529125 @default.
• W3007458722 cites W2064462284 @default.
• W3007458722 cites W2070018868 @default.
• W3007458722 cites W2078198011 @default.
• W3007458722 cites W2079257101 @default.
• W3007458722 cites W2086796078 @default.
• W3007458722 cites W2088665358 @default.
• W3007458722 cites W2098971151 @default.
• W3007458722 cites W2133621493 @default.
• W3007458722 cites W2135597753 @default.
• W3007458722 cites W2142179347 @default.
• W3007458722 cites W2172133264 @default.
• W3007458722 cites W23717086 @default.
• W3007458722 cites W2743382149 @default.
• W3007458722 cites W2789351507 @default.
• W3007458722 cites W2888519458 @default.
• W3007458722 cites W2899493560 @default.
• W3007458722 cites W334939553 @default.
• W3007458722 doi "https://doi.org/10.1038/s41598-020-60263-4" @default.
• W3007458722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7035334" @default.
• W3007458722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32081966" @default.
• W3007458722 hasPublicationYear "2020" @default.
• W3007458722 type Work @default.
• W3007458722 sameAs 3007458722 @default.
• W3007458722 citedByCount "13" @default.
• W3007458722 countsByYear W30074587222020 @default.
• W3007458722 countsByYear W30074587222021 @default.
• W3007458722 countsByYear W30074587222022 @default.
• W3007458722 countsByYear W30074587222023 @default.
• W3007458722 crossrefType "journal-article" @default.
• W3007458722 hasAuthorship W3007458722A5018126677 @default.
• W3007458722 hasAuthorship W3007458722A5023790849 @default.
• W3007458722 hasAuthorship W3007458722A5062469929 @default.
• W3007458722 hasBestOaLocation W30074587221 @default.
• W3007458722 hasConcept C104317684 @default.
• W3007458722 hasConcept C12554922 @default.
• W3007458722 hasConcept C133571119 @default.
• W3007458722 hasConcept C181199279 @default.
• W3007458722 hasConcept C185592680 @default.
• W3007458722 hasConcept C2776165026 @default.
• W3007458722 hasConcept C2777339483 @default.
• W3007458722 hasConcept C2778913249 @default.
• W3007458722 hasConcept C2780883830 @default.
• W3007458722 hasConcept C41183919 @default.
• W3007458722 hasConcept C547475151 @default.
• W3007458722 hasConcept C55493867 @default.
• W3007458722 hasConcept C86803240 @default.
• W3007458722 hasConceptScore W3007458722C104317684 @default.
• W3007458722 hasConceptScore W3007458722C12554922 @default.
• W3007458722 hasConceptScore W3007458722C133571119 @default.
• W3007458722 hasConceptScore W3007458722C181199279 @default.
• W3007458722 hasConceptScore W3007458722C185592680 @default.
• W3007458722 hasConceptScore W3007458722C2776165026 @default.
• W3007458722 hasConceptScore W3007458722C2777339483 @default.
• W3007458722 hasConceptScore W3007458722C2778913249 @default.
• W3007458722 hasConceptScore W3007458722C2780883830 @default.
• W3007458722 hasConceptScore W3007458722C41183919 @default.
• W3007458722 hasConceptScore W3007458722C547475151 @default.
• W3007458722 hasConceptScore W3007458722C55493867 @default.
• W3007458722 hasConceptScore W3007458722C86803240 @default.
• W3007458722 hasIssue "1" @default.
• W3007458722 hasLocation W30074587221 @default.
• W3007458722 hasLocation W30074587222 @default.
• W3007458722 hasLocation W30074587223 @default.
• W3007458722 hasOpenAccess W3007458722 @default.
• W3007458722 hasPrimaryLocation W30074587221 @default.

• next