Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007464906> ?p ?o ?g. }
- W3007464906 abstract "Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. The pathogenesis of MS involves both genetic susceptibility and exposure to distinct environmental risk factors. The gene x environment interaction is regulated by epigenetic mechanisms. Epigenetics refers to a complex system that modifies gene expression without altering the DNA sequence. The most studied epigenetic mechanism is DNA methylation. This epigenetic mark participates in distinct MS pathophysiological processes, including blood–brain barrier breakdown, inflammatory response, demyelination, remyelination failure and neurodegeneration. In this study, we also accurately summarised a list of environmental factors involved in the MS pathogenesis and its clinical course. A literature search was conducted using MEDLINE through PubMED and Scopus. In conclusion, an exhaustive study of DNA methylation might contribute towards new pharmacological interventions in MS by use of epigenetic drugs." @default.
- W3007464906 created "2020-03-06" @default.
- W3007464906 creator A5010983976 @default.
- W3007464906 creator A5090879641 @default.
- W3007464906 date "2020-01-14" @default.
- W3007464906 modified "2023-10-09" @default.
- W3007464906 title "Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients" @default.
- W3007464906 cites W1536928673 @default.
- W3007464906 cites W1538563548 @default.
- W3007464906 cites W1550823327 @default.
- W3007464906 cites W1553219309 @default.
- W3007464906 cites W1606607436 @default.
- W3007464906 cites W1607206274 @default.
- W3007464906 cites W1650463686 @default.
- W3007464906 cites W1824732500 @default.
- W3007464906 cites W1834417670 @default.
- W3007464906 cites W1866034006 @default.
- W3007464906 cites W1918237073 @default.
- W3007464906 cites W1940971508 @default.
- W3007464906 cites W1942368010 @default.
- W3007464906 cites W1950692893 @default.
- W3007464906 cites W1963527597 @default.
- W3007464906 cites W1966922842 @default.
- W3007464906 cites W1967616873 @default.
- W3007464906 cites W1967841068 @default.
- W3007464906 cites W1976844387 @default.
- W3007464906 cites W1978026859 @default.
- W3007464906 cites W1979638914 @default.
- W3007464906 cites W1981463058 @default.
- W3007464906 cites W1982110038 @default.
- W3007464906 cites W1982832616 @default.
- W3007464906 cites W1986037132 @default.
- W3007464906 cites W1989306342 @default.
- W3007464906 cites W1989999563 @default.
- W3007464906 cites W1992667426 @default.
- W3007464906 cites W1992677786 @default.
- W3007464906 cites W1993762503 @default.
- W3007464906 cites W1994471840 @default.
- W3007464906 cites W1994708664 @default.
- W3007464906 cites W1995353727 @default.
- W3007464906 cites W1997078385 @default.
- W3007464906 cites W1997453048 @default.
- W3007464906 cites W1998139699 @default.
- W3007464906 cites W1998517881 @default.
- W3007464906 cites W1999024498 @default.
- W3007464906 cites W1999745515 @default.
- W3007464906 cites W2000173371 @default.
- W3007464906 cites W2002333515 @default.
- W3007464906 cites W2004522121 @default.
- W3007464906 cites W2004552736 @default.
- W3007464906 cites W2006137635 @default.
- W3007464906 cites W2006345816 @default.
- W3007464906 cites W2007217012 @default.
- W3007464906 cites W2014232971 @default.
- W3007464906 cites W2015293007 @default.
- W3007464906 cites W2016835287 @default.
- W3007464906 cites W2019009797 @default.
- W3007464906 cites W2019527553 @default.
- W3007464906 cites W2020121188 @default.
- W3007464906 cites W2020283231 @default.
- W3007464906 cites W2021012003 @default.
- W3007464906 cites W2023300261 @default.
- W3007464906 cites W2023765801 @default.
- W3007464906 cites W2026217309 @default.
- W3007464906 cites W2028423120 @default.
- W3007464906 cites W2032882684 @default.
- W3007464906 cites W2033516350 @default.
- W3007464906 cites W2034811712 @default.
- W3007464906 cites W2036286832 @default.
- W3007464906 cites W2037907937 @default.
- W3007464906 cites W2038757125 @default.
- W3007464906 cites W2044867724 @default.
- W3007464906 cites W2046457054 @default.
- W3007464906 cites W2050377050 @default.
- W3007464906 cites W2054395536 @default.
- W3007464906 cites W2055553707 @default.
- W3007464906 cites W2055909692 @default.
- W3007464906 cites W2056842797 @default.
- W3007464906 cites W2057242511 @default.
- W3007464906 cites W2058214824 @default.
- W3007464906 cites W2062211740 @default.
- W3007464906 cites W2062326815 @default.
- W3007464906 cites W2062818758 @default.
- W3007464906 cites W2067255906 @default.
- W3007464906 cites W2069027667 @default.
- W3007464906 cites W2069558724 @default.
- W3007464906 cites W2074264738 @default.
- W3007464906 cites W2074924223 @default.
- W3007464906 cites W2079817384 @default.
- W3007464906 cites W2083470832 @default.
- W3007464906 cites W2085278496 @default.
- W3007464906 cites W2085327078 @default.
- W3007464906 cites W2087398290 @default.
- W3007464906 cites W2089941463 @default.
- W3007464906 cites W2100904149 @default.
- W3007464906 cites W2103502637 @default.
- W3007464906 cites W2109592485 @default.
- W3007464906 cites W2111245109 @default.
- W3007464906 cites W2113315025 @default.
- W3007464906 cites W2113648153 @default.