FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007485087> ?p ?o ?g. }

• W3007485087 endingPage "e1008334" @default.
• W3007485087 startingPage "e1008334" @default.
• W3007485087 abstract "Influenza A virus (IAV) infection is a complicated process. After IAVs spread to the lung, extensive pro-inflammatory cytokines and chemokines are released, which largely determine the outcome of infection. Using a single-cell RNA sequencing (scRNA-seq) assay, we systematically and sequentially analyzed the transcriptome of more than 16,000 immune cells in the pulmonary tissue of infected mice, and demonstrated that two waves of pro-inflammatory factors were released. A group of IAV-infected PD-L1+ neutrophils were the major contributor to the first wave at an earlier stage (day 1–3 post infection). Notably, at a later stage (day 7 post infection) when IAV was hardly detected in the immune cells, a group of platelet factor 4-positive (Pf4+)-macrophages generated another wave of pro-inflammatory factors, which were probably the precursors of alveolar macrophages (AMs). Furthermore, single-cell signaling map identified inter-lineage crosstalk between different clusters and helped better understand the signature of PD-L1+ neutrophils and Pf4+-macrophages. Our data characteristically clarified the infiltrated immune cells and their production of pro-inflammatory factors during the immunopathogenesis development, and deciphered the important mechanisms underlying IAV-driven inflammatory reactions in the lung." @default.
• W3007485087 created "2020-03-06" @default.
• W3007485087 creator A5003596217 @default.
• W3007485087 creator A5003759585 @default.
• W3007485087 creator A5005616906 @default.
• W3007485087 creator A5026041527 @default.
• W3007485087 creator A5027835055 @default.
• W3007485087 creator A5033899914 @default.
• W3007485087 creator A5035674407 @default.
• W3007485087 creator A5044741431 @default.
• W3007485087 creator A5047495310 @default.
• W3007485087 creator A5047764487 @default.
• W3007485087 creator A5062373772 @default.
• W3007485087 creator A5070245791 @default.
• W3007485087 creator A5073568638 @default.
• W3007485087 creator A5084462276 @default.
• W3007485087 creator A5085927169 @default.
• W3007485087 creator A5091326309 @default.
• W3007485087 creator A5091685833 @default.
• W3007485087 date "2020-02-26" @default.
• W3007485087 modified "2023-10-16" @default.
• W3007485087 title "Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis" @default.
• W3007485087 cites W1966952910 @default.
• W3007485087 cites W1968541274 @default.
• W3007485087 cites W1973433801 @default.
• W3007485087 cites W1974668319 @default.
• W3007485087 cites W1975857445 @default.
• W3007485087 cites W1996311210 @default.
• W3007485087 cites W2032725983 @default.
• W3007485087 cites W2037730374 @default.
• W3007485087 cites W2066586758 @default.
• W3007485087 cites W2070058005 @default.
• W3007485087 cites W2071010503 @default.
• W3007485087 cites W2071688420 @default.
• W3007485087 cites W2112687224 @default.
• W3007485087 cites W2158217645 @default.
• W3007485087 cites W2334539119 @default.
• W3007485087 cites W2534495179 @default.
• W3007485087 cites W2600669583 @default.
• W3007485087 cites W2736034593 @default.
• W3007485087 cites W2743416243 @default.
• W3007485087 cites W2755681539 @default.
• W3007485087 cites W2759082725 @default.
• W3007485087 cites W2762703589 @default.
• W3007485087 cites W2763051133 @default.
• W3007485087 cites W2767487209 @default.
• W3007485087 cites W2782711761 @default.
• W3007485087 cites W2785854718 @default.
• W3007485087 cites W2793411374 @default.
• W3007485087 cites W2794480084 @default.
• W3007485087 cites W2801418288 @default.
• W3007485087 cites W2803990310 @default.
• W3007485087 cites W2805415936 @default.
• W3007485087 cites W2885781875 @default.
• W3007485087 cites W2896222795 @default.
• W3007485087 cites W2907471984 @default.
• W3007485087 cites W2907614968 @default.
• W3007485087 cites W2944868902 @default.
• W3007485087 cites W2951506174 @default.
• W3007485087 cites W2953162568 @default.
• W3007485087 cites W4251287806 @default.
• W3007485087 doi "https://doi.org/10.1371/journal.ppat.1008334" @default.
• W3007485087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7062283" @default.
• W3007485087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32101596" @default.
• W3007485087 hasPublicationYear "2020" @default.
• W3007485087 type Work @default.
• W3007485087 sameAs 3007485087 @default.
• W3007485087 citedByCount "31" @default.
• W3007485087 countsByYear W30074850872020 @default.
• W3007485087 countsByYear W30074850872021 @default.
• W3007485087 countsByYear W30074850872022 @default.
• W3007485087 countsByYear W30074850872023 @default.
• W3007485087 crossrefType "journal-article" @default.
• W3007485087 hasAuthorship W3007485087A5003596217 @default.
• W3007485087 hasAuthorship W3007485087A5003759585 @default.
• W3007485087 hasAuthorship W3007485087A5005616906 @default.
• W3007485087 hasAuthorship W3007485087A5026041527 @default.
• W3007485087 hasAuthorship W3007485087A5027835055 @default.
• W3007485087 hasAuthorship W3007485087A5033899914 @default.
• W3007485087 hasAuthorship W3007485087A5035674407 @default.
• W3007485087 hasAuthorship W3007485087A5044741431 @default.
• W3007485087 hasAuthorship W3007485087A5047495310 @default.
• W3007485087 hasAuthorship W3007485087A5047764487 @default.
• W3007485087 hasAuthorship W3007485087A5062373772 @default.
• W3007485087 hasAuthorship W3007485087A5070245791 @default.
• W3007485087 hasAuthorship W3007485087A5073568638 @default.
• W3007485087 hasAuthorship W3007485087A5084462276 @default.
• W3007485087 hasAuthorship W3007485087A5085927169 @default.
• W3007485087 hasAuthorship W3007485087A5091326309 @default.
• W3007485087 hasAuthorship W3007485087A5091685833 @default.
• W3007485087 hasBestOaLocation W30074850871 @default.
• W3007485087 hasConcept C104317684 @default.
• W3007485087 hasConcept C120665830 @default.
• W3007485087 hasConcept C121332964 @default.
• W3007485087 hasConcept C13373296 @default.
• W3007485087 hasConcept C150194340 @default.
• W3007485087 hasConcept C162317418 @default.
• W3007485087 hasConcept C164027704 @default.

• next