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• W3007506723 abstract "Neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. Microglial cells are the main immune cells of the central nervous system. On exposure to lipopolysaccharides (LPS, components of the cell wall of Gram-negative enterobacteria), microglia is activated to produce reactive oxygen species (ROS), cytokines, and inflammatory mediators, which may cause neuron death. Exogenous recombinant human heat shock protein 70 (HSP70) was tested for effect on the activation of human microglial and neuroblastoma cells in response to LPS from Escherichia coli. Experiments included cell cultivation separately and transferring the conditioned medium from A-172 microglial cells to SK-N-SH neuroblastoma cells to simulate the effect of microglia treated with LPS and/or HSP70. The levels of ROS, TNFα, and apoptosis in LPS-treated cells were estimated in the presence or absence of HSP70. HSP70 was found to reduce the LPS-induced ROS generation, TNFα production, apoptosis, and necrosis, in both separate cell cultures and neuroblastoma cells grown in the conditioned medium from microglial cells. Signaling pathways involving protein kinases p38MAPK, JNK, and PI3K were demonstrated to play an important role in HSP70-mediated protection of microglial and neuroblastoma cells from LPS-induced apoptosis and ROS production." @default.
• W3007506723 created "2020-03-06" @default.
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• W3007506723 date "2020-01-01" @default.
• W3007506723 modified "2023-09-23" @default.
• W3007506723 title "Экзогенный БТШ70 и сигнальные пути, участвующие в ингибировании индуцированной липополисахаридом нейротоксичности клеток нейробластомы" @default.
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• W3007506723 doi "https://doi.org/10.31857/s0026898420010164" @default.
• W3007506723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32163396" @default.
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