FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007554544> ?p ?o ?g. }

• W3007554544 abstract "Abstract Altered pulmonary angiogenesis contributes to disrupted alveolarization, which is the main characteristic of bronchopulmonary dysplasia (BPD). Transforming growth factor β (TGFβ) plays an important role during lung vascular development, and recent studies have demonstrated that endoglin is engaged in the modulation of TGFβ downstream signalling. Although there are two different isoforms of endoglin, L- and S-endoglin, little is known about the effect of S-endoglin in developing lungs. We analysed the expression of both L- and S-endoglin in the lung vasculature and its contribution to TGFβ-activin-like kinase (ALK)-Smad signalling with respect to BPD development. Hyperoxia impaired pulmonary angiogenesis accompanied by alveolar simplification in neonatal mouse lungs. S-endoglin, phosphorylated Smad2/3 and connective tissue growth factor levels were significantly increased in hyperoxia-exposed mice, while L-endoglin, phosphor-Smad1/5 and platelet-endothelial cell adhesion molecule-1 levels were significantly decreased. Hyperoxia suppressed the tubular growth of human pulmonary microvascular endothelial cells (ECs), and the selective inhibition of ALK5 signalling restored tubular growth. These results indicate that hyperoxia alters the balance in two isoforms of endoglin towards increased S-endoglin and that S-endoglin attenuates TGFβ-ALK1-Smad1/5 signalling but stimulates TGFβ-ALK5-Smad2/3 signalling in pulmonary ECs, which may lead to impaired pulmonary angiogenesis in developing lungs." @default.
• W3007554544 created "2020-03-06" @default.
• W3007554544 creator A5004238629 @default.
• W3007554544 creator A5046182752 @default.
• W3007554544 creator A5078317253 @default.
• W3007554544 creator A5082306790 @default.
• W3007554544 date "2020-02-20" @default.
• W3007554544 modified "2023-10-16" @default.
• W3007554544 title "S-endoglin expression is induced in hyperoxia and contributes to altered pulmonary angiogenesis in bronchopulmonary dysplasia development" @default.
• W3007554544 cites W1523878042 @default.
• W3007554544 cites W1574697834 @default.
• W3007554544 cites W1577109893 @default.
• W3007554544 cites W1732498503 @default.
• W3007554544 cites W1913648337 @default.
• W3007554544 cites W1969587708 @default.
• W3007554544 cites W1974387205 @default.
• W3007554544 cites W1978261553 @default.
• W3007554544 cites W1978274615 @default.
• W3007554544 cites W1989851229 @default.
• W3007554544 cites W2001065358 @default.
• W3007554544 cites W2007684837 @default.
• W3007554544 cites W2009529606 @default.
• W3007554544 cites W2013958991 @default.
• W3007554544 cites W2019983576 @default.
• W3007554544 cites W2022211980 @default.
• W3007554544 cites W2024784351 @default.
• W3007554544 cites W2033505903 @default.
• W3007554544 cites W2038304860 @default.
• W3007554544 cites W2046087773 @default.
• W3007554544 cites W2049995230 @default.
• W3007554544 cites W2054288412 @default.
• W3007554544 cites W2059284026 @default.
• W3007554544 cites W2066905497 @default.
• W3007554544 cites W2073312831 @default.
• W3007554544 cites W2079326731 @default.
• W3007554544 cites W2084473102 @default.
• W3007554544 cites W2088502271 @default.
• W3007554544 cites W2089288497 @default.
• W3007554544 cites W2094787322 @default.
• W3007554544 cites W2095025412 @default.
• W3007554544 cites W2097718638 @default.
• W3007554544 cites W2100825082 @default.
• W3007554544 cites W2113449196 @default.
• W3007554544 cites W2116293168 @default.
• W3007554544 cites W2116816667 @default.
• W3007554544 cites W2119177540 @default.
• W3007554544 cites W2119332119 @default.
• W3007554544 cites W2119440632 @default.
• W3007554544 cites W2122124110 @default.
• W3007554544 cites W2122751325 @default.
• W3007554544 cites W2123137262 @default.
• W3007554544 cites W2127776747 @default.
• W3007554544 cites W2127797490 @default.
• W3007554544 cites W2128005193 @default.
• W3007554544 cites W2132860482 @default.
• W3007554544 cites W2147005799 @default.
• W3007554544 cites W2197255439 @default.
• W3007554544 cites W2461343632 @default.
• W3007554544 cites W2520780150 @default.
• W3007554544 cites W2608442917 @default.
• W3007554544 cites W2617485792 @default.
• W3007554544 cites W2647212460 @default.
• W3007554544 cites W2765990633 @default.
• W3007554544 cites W2791229556 @default.
• W3007554544 cites W2792673281 @default.
• W3007554544 cites W2795881597 @default.
• W3007554544 cites W2885085538 @default.
• W3007554544 cites W2889891118 @default.
• W3007554544 cites W2891497275 @default.
• W3007554544 cites W2900994280 @default.
• W3007554544 cites W2914601883 @default.
• W3007554544 doi "https://doi.org/10.1038/s41598-020-59928-x" @default.
• W3007554544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7033222" @default.
• W3007554544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32080296" @default.
• W3007554544 hasPublicationYear "2020" @default.
• W3007554544 type Work @default.
• W3007554544 sameAs 3007554544 @default.
• W3007554544 citedByCount "12" @default.
• W3007554544 countsByYear W30075545442020 @default.
• W3007554544 countsByYear W30075545442021 @default.
• W3007554544 countsByYear W30075545442022 @default.
• W3007554544 countsByYear W30075545442023 @default.
• W3007554544 crossrefType "journal-article" @default.
• W3007554544 hasAuthorship W3007554544A5004238629 @default.
• W3007554544 hasAuthorship W3007554544A5046182752 @default.
• W3007554544 hasAuthorship W3007554544A5078317253 @default.
• W3007554544 hasAuthorship W3007554544A5082306790 @default.
• W3007554544 hasBestOaLocation W30075545441 @default.
• W3007554544 hasConcept C10205521 @default.
• W3007554544 hasConcept C118131993 @default.
• W3007554544 hasConcept C126322002 @default.
• W3007554544 hasConcept C2777714996 @default.
• W3007554544 hasConcept C2778376644 @default.
• W3007554544 hasConcept C2778721537 @default.
• W3007554544 hasConcept C2779234561 @default.
• W3007554544 hasConcept C2780394083 @default.
• W3007554544 hasConcept C2780672939 @default.
• W3007554544 hasConcept C28328180 @default.
• W3007554544 hasConcept C502942594 @default.
• W3007554544 hasConcept C54355233 @default.

• next