Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007589613> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3007589613 endingPage "S122" @default.
- W3007589613 startingPage "S121" @default.
- W3007589613 abstract "Anti-glomerular basement membrane (GBM) autoantibodies are associated with Goodpasture’s syndrome, characterised by lung and kidney involvement. We report a case with clinical disease demonstrating discrepant anti-GBM antibody results between assay platforms. A 39-year-old male presented with an eight-week history of haemoptysis and acute renal impairment, on a background of active hepatitis C infection. Creatinine was 256 μmol/L with haemoproteinuria, hypocomplementaemia, and positive anti-GBM level (65 U/mL Phadia ELiA; reference range >10 U/mL) which was confirmed on repeat testing. Treatment for Goodpasture’s syndrome was initiated with plasma exchange (PLEX) and intravenous cyclophosphamide. However, renal biopsy performed in parallel to treatment did not demonstrate characteristic linear GBM binding on direct immunofluorescence. Findings were instead consistent with hepatitis C-associated glomerulonephritis. ANCA by immunofluorescence was negative. Anti-PR3, anti-MPO and anti-CCP tested retrospectively by Phadia ELiA methods were also positive, raising suspicion for an interfering factor. Pre-treatment sera tested for anti-GBM antibodies via indirect immunofluorescence (INOVA primate kidney) and chemiluminescence assay (INOVA BIO-FLASH) were negative. Unfortunately, pre-treatment cryoglobulins had not been tested. However, testing 6 months after presentation confirmed type 2 cryoglobulins, and anti-GBM levels had normalised. Cryoglobulins or another interfering factor may have caused platform-specific assay interference, affecting anti-GBM and other autoantibody detection on the same platform." @default.
- W3007589613 created "2020-03-06" @default.
- W3007589613 creator A5002187513 @default.
- W3007589613 creator A5025209824 @default.
- W3007589613 creator A5034985450 @default.
- W3007589613 creator A5050582455 @default.
- W3007589613 creator A5089577372 @default.
- W3007589613 date "2020-02-01" @default.
- W3007589613 modified "2023-10-17" @default.
- W3007589613 title "Hepatitis C-associated glomerulonephritis masquerading as Goodpasture’s syndrome" @default.
- W3007589613 doi "https://doi.org/10.1016/j.pathol.2020.01.413" @default.
- W3007589613 hasPublicationYear "2020" @default.
- W3007589613 type Work @default.
- W3007589613 sameAs 3007589613 @default.
- W3007589613 citedByCount "0" @default.
- W3007589613 crossrefType "journal-article" @default.
- W3007589613 hasAuthorship W3007589613A5002187513 @default.
- W3007589613 hasAuthorship W3007589613A5025209824 @default.
- W3007589613 hasAuthorship W3007589613A5034985450 @default.
- W3007589613 hasAuthorship W3007589613A5050582455 @default.
- W3007589613 hasAuthorship W3007589613A5089577372 @default.
- W3007589613 hasConcept C126322002 @default.
- W3007589613 hasConcept C142724271 @default.
- W3007589613 hasConcept C159654299 @default.
- W3007589613 hasConcept C163764329 @default.
- W3007589613 hasConcept C203014093 @default.
- W3007589613 hasConcept C2522874641 @default.
- W3007589613 hasConcept C2775998817 @default.
- W3007589613 hasConcept C2776029263 @default.
- W3007589613 hasConcept C2776115139 @default.
- W3007589613 hasConcept C2776408679 @default.
- W3007589613 hasConcept C2776455275 @default.
- W3007589613 hasConcept C2777234017 @default.
- W3007589613 hasConcept C2778236600 @default.
- W3007589613 hasConcept C2778922544 @default.
- W3007589613 hasConcept C2780091579 @default.
- W3007589613 hasConcept C2780368995 @default.
- W3007589613 hasConcept C2909524538 @default.
- W3007589613 hasConcept C2910612865 @default.
- W3007589613 hasConcept C71924100 @default.
- W3007589613 hasConceptScore W3007589613C126322002 @default.
- W3007589613 hasConceptScore W3007589613C142724271 @default.
- W3007589613 hasConceptScore W3007589613C159654299 @default.
- W3007589613 hasConceptScore W3007589613C163764329 @default.
- W3007589613 hasConceptScore W3007589613C203014093 @default.
- W3007589613 hasConceptScore W3007589613C2522874641 @default.
- W3007589613 hasConceptScore W3007589613C2775998817 @default.
- W3007589613 hasConceptScore W3007589613C2776029263 @default.
- W3007589613 hasConceptScore W3007589613C2776115139 @default.
- W3007589613 hasConceptScore W3007589613C2776408679 @default.
- W3007589613 hasConceptScore W3007589613C2776455275 @default.
- W3007589613 hasConceptScore W3007589613C2777234017 @default.
- W3007589613 hasConceptScore W3007589613C2778236600 @default.
- W3007589613 hasConceptScore W3007589613C2778922544 @default.
- W3007589613 hasConceptScore W3007589613C2780091579 @default.
- W3007589613 hasConceptScore W3007589613C2780368995 @default.
- W3007589613 hasConceptScore W3007589613C2909524538 @default.
- W3007589613 hasConceptScore W3007589613C2910612865 @default.
- W3007589613 hasConceptScore W3007589613C71924100 @default.
- W3007589613 hasLocation W30075896131 @default.
- W3007589613 hasOpenAccess W3007589613 @default.
- W3007589613 hasPrimaryLocation W30075896131 @default.
- W3007589613 hasRelatedWork W166121715 @default.
- W3007589613 hasRelatedWork W1964608434 @default.
- W3007589613 hasRelatedWork W2004780017 @default.
- W3007589613 hasRelatedWork W2005746644 @default.
- W3007589613 hasRelatedWork W2065351142 @default.
- W3007589613 hasRelatedWork W2246997449 @default.
- W3007589613 hasRelatedWork W2610050121 @default.
- W3007589613 hasRelatedWork W2619798031 @default.
- W3007589613 hasRelatedWork W2994065059 @default.
- W3007589613 hasRelatedWork W4361273535 @default.
- W3007589613 hasVolume "52" @default.
- W3007589613 isParatext "false" @default.
- W3007589613 isRetracted "false" @default.
- W3007589613 magId "3007589613" @default.
- W3007589613 workType "article" @default.