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- W3007636517 abstract "Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications." @default.
- W3007636517 created "2020-03-06" @default.
- W3007636517 creator A5015152144 @default.
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- W3007636517 date "2020-02-26" @default.
- W3007636517 modified "2023-10-16" @default.
- W3007636517 title "Oxidative Stress and Atopic Dermatitis" @default.
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- W3007636517 doi "https://doi.org/10.3390/antiox9030196" @default.
- W3007636517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7139929" @default.
- W3007636517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32111015" @default.
- W3007636517 hasPublicationYear "2020" @default.
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