FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007667066> ?p ?o ?g. }

• W3007667066 abstract "Selenium is a trace element for most organisms; its deficiency and excess are detrimental. Selenium beneficial effects are mainly due to the role of the 21st genetically encoded amino acid selenocysteine (Sec). Selenium also exerts Sec- independent beneficial effects. Its harmful effects are thought to be mainly due non-specific incorporation in protein synthesis. Yet the selenium response in animals is poorly understood. In C. elegans, Sec is genetically incorporated into a single selenoprotein. Similar to mammals, a 20-fold excess of the optimal selenium requirement is harmful. Selenite excess induces oxidative stress and causes development retardation, impaired growth, and neurodegeneration of motor neurons. To study the organismal response to selenium we performed a genetic screen for C. elegans mutants that are resistant to selenite. We isolated a non-sense and a missense egl-9/EGLN mutants that confer robust resistance to selenium. In contrast, hif-1/HIF null mutant was highly sensitive to selenium, establishing a role for this transcription factor in the selenium response. We showed that EGL-9 regulates HIF-1 activity through VHL-1, and identified CYSL-1 as a key sensor that transduces the selenium signal. Finally, we showed that the key enzymes involved in sulfide and sulfite stress (sulfide quinone oxidoreductase and sulfite oxidase) are not required for selenium resistance. In contrast, knockout strains in the persulfide dioxygenase ETHE-1 and the sulfur transferase MPST-7 affect the organismal response to selenium. In sum, our results identified a transcriptional pathway as well as enzymes involved in the organismal selenium response." @default.
• W3007667066 created "2020-03-06" @default.
• W3007667066 creator A5032843339 @default.
• W3007667066 creator A5035148494 @default.
• W3007667066 creator A5058821021 @default.
• W3007667066 creator A5069123496 @default.
• W3007667066 date "2020-02-25" @default.
• W3007667066 modified "2023-09-30" @default.
• W3007667066 title "HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium" @default.
• W3007667066 cites W1430821294 @default.
• W3007667066 cites W1668286863 @default.
• W3007667066 cites W1921244251 @default.
• W3007667066 cites W1963780213 @default.
• W3007667066 cites W1964880819 @default.
• W3007667066 cites W1967696309 @default.
• W3007667066 cites W1976861608 @default.
• W3007667066 cites W1982882767 @default.
• W3007667066 cites W1986330164 @default.
• W3007667066 cites W1988065937 @default.
• W3007667066 cites W2001666774 @default.
• W3007667066 cites W2005868568 @default.
• W3007667066 cites W2009080781 @default.
• W3007667066 cites W2009806314 @default.
• W3007667066 cites W2018824728 @default.
• W3007667066 cites W2020687059 @default.
• W3007667066 cites W2024206845 @default.
• W3007667066 cites W2026393494 @default.
• W3007667066 cites W2030634993 @default.
• W3007667066 cites W2033594658 @default.
• W3007667066 cites W2033745200 @default.
• W3007667066 cites W2034313285 @default.
• W3007667066 cites W2045759431 @default.
• W3007667066 cites W2051575707 @default.
• W3007667066 cites W2067533449 @default.
• W3007667066 cites W2070629606 @default.
• W3007667066 cites W2071302550 @default.
• W3007667066 cites W2072117025 @default.
• W3007667066 cites W2077683965 @default.
• W3007667066 cites W2081645231 @default.
• W3007667066 cites W2084748090 @default.
• W3007667066 cites W2086257151 @default.
• W3007667066 cites W2086400957 @default.
• W3007667066 cites W2089600895 @default.
• W3007667066 cites W2097803924 @default.
• W3007667066 cites W2099752867 @default.
• W3007667066 cites W2102274260 @default.
• W3007667066 cites W2110583844 @default.
• W3007667066 cites W2116186771 @default.
• W3007667066 cites W2122753552 @default.
• W3007667066 cites W2152002370 @default.
• W3007667066 cites W2159563080 @default.
• W3007667066 cites W2161500896 @default.
• W3007667066 cites W2168082814 @default.
• W3007667066 cites W2168433858 @default.
• W3007667066 cites W2256390272 @default.
• W3007667066 cites W2401299463 @default.
• W3007667066 cites W2519752850 @default.
• W3007667066 cites W2531440968 @default.
• W3007667066 cites W2767914703 @default.
• W3007667066 cites W2802235444 @default.
• W3007667066 cites W2959595486 @default.
• W3007667066 cites W4235514161 @default.
• W3007667066 cites W42493334 @default.
• W3007667066 cites W4256096473 @default.
• W3007667066 doi "https://doi.org/10.3389/fgene.2020.00063" @default.
• W3007667066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7052493" @default.
• W3007667066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32161616" @default.
• W3007667066 hasPublicationYear "2020" @default.
• W3007667066 type Work @default.
• W3007667066 sameAs 3007667066 @default.
• W3007667066 citedByCount "6" @default.
• W3007667066 countsByYear W30076670662021 @default.
• W3007667066 countsByYear W30076670662022 @default.
• W3007667066 crossrefType "journal-article" @default.
• W3007667066 hasAuthorship W3007667066A5032843339 @default.
• W3007667066 hasAuthorship W3007667066A5035148494 @default.
• W3007667066 hasAuthorship W3007667066A5058821021 @default.
• W3007667066 hasAuthorship W3007667066A5069123496 @default.
• W3007667066 hasBestOaLocation W30076670661 @default.
• W3007667066 hasConcept C104317684 @default.
• W3007667066 hasConcept C143065580 @default.
• W3007667066 hasConcept C178790620 @default.
• W3007667066 hasConcept C181199279 @default.
• W3007667066 hasConcept C185592680 @default.
• W3007667066 hasConcept C2775838275 @default.
• W3007667066 hasConcept C2776087148 @default.
• W3007667066 hasConcept C2776151105 @default.
• W3007667066 hasConcept C2776841403 @default.
• W3007667066 hasConcept C2778760513 @default.
• W3007667066 hasConcept C2778944004 @default.
• W3007667066 hasConcept C2779033446 @default.
• W3007667066 hasConcept C2779201268 @default.
• W3007667066 hasConcept C2780104201 @default.
• W3007667066 hasConcept C54355233 @default.
• W3007667066 hasConcept C553756173 @default.
• W3007667066 hasConcept C55493867 @default.
• W3007667066 hasConcept C86803240 @default.
• W3007667066 hasConcept C95444343 @default.
• W3007667066 hasConceptScore W3007667066C104317684 @default.
• W3007667066 hasConceptScore W3007667066C143065580 @default.

• next