FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007672038> ?p ?o ?g. }

• W3007672038 abstract "Abstract Background Recurrence and distant metastasis are still the main factors leading to treatment failure for malignant tumors including nasopharyngeal carcinoma (NPC). Therefore, elucidating the molecular mechanisms underlying nasopharyngeal carcinoma metastasis is of great clinical significance for targeted gene therapy and prognostic evaluation. PinX1, a tumor suppressor gene, was previously demonstrated to be a powerful tool for targeting telomerase in order to resist malignant tumor proliferation and migration. The aim of this study was to explore the mechanism through which PinX1 regulates epithelial–mesenchymal transition (EMT) and tumor metastasis in NPC and investigate its clinical significance and biological role with respect to disease progression. Methods Cell Counting Kit-8 (CCK8), Transwell assays, Colony formation analysis and Xenograft tumorigenicity assay were used to measure the nasopharyngeal CD133 + cancer stem cell proliferation, migration, and invasion abilities. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays were conducted to investigate the underlying mechanism that PinX1 inhibits cell proliferation, migration, and invasion via regulating EMT in nasopharyngeal CD133 + CSCs. Results We found that the overexpression of PinX1 and P53 inhibited cell proliferation, migration, and invasion, but that the inhibition of miR-200b blocked these effects, in nasopharyngeal CD133 + cancer stem cells (CSCs). Mechanistic investigations elucidated that PinX1 inhibits cell proliferation, migration, and invasion by regulating the P53/miR-200b-mediated transcriptional suppression of Snail1, Twist1, and Zeb1, consequently inhibiting EMT in nasopharyngeal CD133 + CSCs. Conclusions Our findings indicate that PinX1 inhibits cell proliferation, migration, and invasion via P53/miR-200b-regulated EMT in the malignant progression of human NPC, which might suggest novel clinical implications for disease treatment." @default.
• W3007672038 created "2020-03-06" @default.
• W3007672038 creator A5042779459 @default.
• W3007672038 creator A5052493382 @default.
• W3007672038 creator A5058551421 @default.
• W3007672038 creator A5059184457 @default.
• W3007672038 creator A5060339883 @default.
• W3007672038 creator A5069732404 @default.
• W3007672038 creator A5071999920 @default.
• W3007672038 creator A5073420488 @default.
• W3007672038 creator A5080841020 @default.
• W3007672038 creator A5086279561 @default.
• W3007672038 date "2020-02-07" @default.
• W3007672038 modified "2023-10-14" @default.
• W3007672038 title "Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting" @default.
• W3007672038 cites W1929116594 @default.
• W3007672038 cites W2000038676 @default.
• W3007672038 cites W2002013266 @default.
• W3007672038 cites W2014691022 @default.
• W3007672038 cites W2015848047 @default.
• W3007672038 cites W2042897772 @default.
• W3007672038 cites W2051663161 @default.
• W3007672038 cites W2066441178 @default.
• W3007672038 cites W2076377928 @default.
• W3007672038 cites W2096106647 @default.
• W3007672038 cites W2107462637 @default.
• W3007672038 cites W2123182611 @default.
• W3007672038 cites W2140532234 @default.
• W3007672038 cites W2150434794 @default.
• W3007672038 cites W2162674813 @default.
• W3007672038 cites W2164561943 @default.
• W3007672038 cites W2297488593 @default.
• W3007672038 cites W2467505649 @default.
• W3007672038 cites W2592149411 @default.
• W3007672038 cites W2621394042 @default.
• W3007672038 cites W2626540658 @default.
• W3007672038 cites W2724125143 @default.
• W3007672038 cites W2736520162 @default.
• W3007672038 cites W2746031475 @default.
• W3007672038 cites W2749342550 @default.
• W3007672038 cites W2758516478 @default.
• W3007672038 cites W2770272946 @default.
• W3007672038 cites W2796759472 @default.
• W3007672038 cites W2808369034 @default.
• W3007672038 cites W2884390993 @default.
• W3007672038 cites W2888390551 @default.
• W3007672038 cites W2891968161 @default.
• W3007672038 cites W2900517606 @default.
• W3007672038 cites W2905792497 @default.
• W3007672038 cites W2907132956 @default.
• W3007672038 cites W2907478649 @default.
• W3007672038 cites W2907731332 @default.
• W3007672038 cites W2914178603 @default.
• W3007672038 cites W2937054473 @default.
• W3007672038 cites W4293384264 @default.
• W3007672038 doi "https://doi.org/10.1186/s13046-020-1530-3" @default.
• W3007672038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7006127" @default.
• W3007672038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32028978" @default.
• W3007672038 hasPublicationYear "2020" @default.
• W3007672038 type Work @default.
• W3007672038 sameAs 3007672038 @default.
• W3007672038 citedByCount "7" @default.
• W3007672038 countsByYear W30076720382020 @default.
• W3007672038 countsByYear W30076720382021 @default.
• W3007672038 countsByYear W30076720382022 @default.
• W3007672038 countsByYear W30076720382023 @default.
• W3007672038 crossrefType "journal-article" @default.
• W3007672038 hasAuthorship W3007672038A5042779459 @default.
• W3007672038 hasAuthorship W3007672038A5052493382 @default.
• W3007672038 hasAuthorship W3007672038A5058551421 @default.
• W3007672038 hasAuthorship W3007672038A5059184457 @default.
• W3007672038 hasAuthorship W3007672038A5060339883 @default.
• W3007672038 hasAuthorship W3007672038A5069732404 @default.
• W3007672038 hasAuthorship W3007672038A5071999920 @default.
• W3007672038 hasAuthorship W3007672038A5073420488 @default.
• W3007672038 hasAuthorship W3007672038A5080841020 @default.
• W3007672038 hasAuthorship W3007672038A5086279561 @default.
• W3007672038 hasBestOaLocation W30076720381 @default.
• W3007672038 hasConcept C104317684 @default.
• W3007672038 hasConcept C121608353 @default.
• W3007672038 hasConcept C125593758 @default.
• W3007672038 hasConcept C126322002 @default.
• W3007672038 hasConcept C137738243 @default.
• W3007672038 hasConcept C1491633281 @default.
• W3007672038 hasConcept C2778997737 @default.
• W3007672038 hasConcept C2779013556 @default.
• W3007672038 hasConcept C2779256057 @default.
• W3007672038 hasConcept C502942594 @default.
• W3007672038 hasConcept C509974204 @default.
• W3007672038 hasConcept C54355233 @default.
• W3007672038 hasConcept C55427017 @default.
• W3007672038 hasConcept C55493867 @default.
• W3007672038 hasConcept C62112901 @default.
• W3007672038 hasConcept C71924100 @default.
• W3007672038 hasConcept C76419328 @default.
• W3007672038 hasConcept C86803240 @default.
• W3007672038 hasConcept C94581717 @default.
• W3007672038 hasConceptScore W3007672038C104317684 @default.
• W3007672038 hasConceptScore W3007672038C121608353 @default.
• W3007672038 hasConceptScore W3007672038C125593758 @default.

• next