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- W3007692225 endingPage "411" @default.
- W3007692225 startingPage "401" @default.
- W3007692225 abstract "Introduction: Esophageal cancer is a deadly disease with high mortality. Treatment with chemotherapy, radiation, and surgery continues to leave many patients with disease progression and recurrence. Novel treatments are needed for this patient population. The development of molecular markers are important for identifying therapeutic targets, as well as prognosis.Areas covered: This review evaluates three molecular markers in esophageal cancer: HER2, PD-L1, and MSI. The fundamentals of these markers, diagnosis, and rates of occurrence in esophageal cancer are explored. The prognostic potential of these markers is based on existing literature as well as application in clinical trials. Key trial findings pertaining to the therapeutic targets for HER2 and PD-1 as well as the role of MSI are discussed.Expert commentary: Molecular markers are changing the practice for esophageal cancer. Therapeutic targeting for HER2 and PD-L1 have shown positive results in recent clinical trials. Trials evaluating immunotherapy as first-line agents are currently underway." @default.
- W3007692225 created "2020-03-06" @default.
- W3007692225 creator A5010129367 @default.
- W3007692225 creator A5061975225 @default.
- W3007692225 date "2020-02-24" @default.
- W3007692225 modified "2023-09-23" @default.
- W3007692225 title "Prognostic and therapeutic molecular markers in the clinical management of esophageal cancer" @default.
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- W3007692225 doi "https://doi.org/10.1080/14737159.2020.1731307" @default.
- W3007692225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32067548" @default.
- W3007692225 hasPublicationYear "2020" @default.
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