Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007702308> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3007702308 endingPage "705" @default.
- W3007702308 startingPage "698" @default.
- W3007702308 abstract "In vivo biosensors are powerful tools for metabolic engineering and synthetic biology applications. However, the development of biosensors is hindered by the limited number of characterized transcriptional regulators. The versatile sensing abilities of microbes and genome sequences available hold great potential for developing novel biosensors via genome mining for new transcriptional regulators. Here we report the development and engineering of a new stilbene-responsive biosensor discovered by mining the Novosphingobium aromaticivorans DSM 12444 genome. The biosensor can distinguish resveratrol from its precursors, p-coumaric acid and trans-cinnamic acid. Remarkably, it can detect other biologically active stilbenes with resorcinol groups, and cannabidiolic acid with a β-resorcylic acid functional group. When coupled to resveratrol biosynthesis enzymes, the biosensor can sense altered resveratrol production in cells, demonstrating a 667-fold enrichment in one round of fluorescence-activated cell sorting. Our biosensor will be potentially applicable to metabolic engineering of microbial cell factories for production of stilbenes and cannabinoids." @default.
- W3007702308 created "2020-03-06" @default.
- W3007702308 creator A5014465828 @default.
- W3007702308 creator A5029041782 @default.
- W3007702308 creator A5066292409 @default.
- W3007702308 date "2020-02-20" @default.
- W3007702308 modified "2023-09-24" @default.
- W3007702308 title "A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator" @default.
- W3007702308 cites W1663057342 @default.
- W3007702308 cites W1872109272 @default.
- W3007702308 cites W1953614311 @default.
- W3007702308 cites W1967901576 @default.
- W3007702308 cites W1975837950 @default.
- W3007702308 cites W2021616727 @default.
- W3007702308 cites W2026531998 @default.
- W3007702308 cites W2030985616 @default.
- W3007702308 cites W2039507504 @default.
- W3007702308 cites W2054990309 @default.
- W3007702308 cites W2088733965 @default.
- W3007702308 cites W2101702198 @default.
- W3007702308 cites W2120232961 @default.
- W3007702308 cites W2123133124 @default.
- W3007702308 cites W2126336673 @default.
- W3007702308 cites W2128262259 @default.
- W3007702308 cites W2130708697 @default.
- W3007702308 cites W2136829424 @default.
- W3007702308 cites W2192981192 @default.
- W3007702308 cites W2273190468 @default.
- W3007702308 cites W2293809279 @default.
- W3007702308 cites W2298122829 @default.
- W3007702308 cites W2322336584 @default.
- W3007702308 cites W2329807975 @default.
- W3007702308 cites W2335148691 @default.
- W3007702308 cites W2523540316 @default.
- W3007702308 cites W2538647793 @default.
- W3007702308 cites W2577386509 @default.
- W3007702308 cites W2732085395 @default.
- W3007702308 cites W2734702993 @default.
- W3007702308 cites W2742556528 @default.
- W3007702308 cites W2745156487 @default.
- W3007702308 cites W2769160949 @default.
- W3007702308 cites W2792233002 @default.
- W3007702308 cites W2793327795 @default.
- W3007702308 cites W2803095132 @default.
- W3007702308 cites W2809645200 @default.
- W3007702308 cites W2810200958 @default.
- W3007702308 cites W2917202476 @default.
- W3007702308 cites W618702716 @default.
- W3007702308 cites W796291325 @default.
- W3007702308 doi "https://doi.org/10.1021/acssynbio.9b00443" @default.
- W3007702308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32078771" @default.
- W3007702308 hasPublicationYear "2020" @default.
- W3007702308 type Work @default.
- W3007702308 sameAs 3007702308 @default.
- W3007702308 citedByCount "24" @default.
- W3007702308 countsByYear W30077023082021 @default.
- W3007702308 countsByYear W30077023082022 @default.
- W3007702308 countsByYear W30077023082023 @default.
- W3007702308 crossrefType "journal-article" @default.
- W3007702308 hasAuthorship W3007702308A5014465828 @default.
- W3007702308 hasAuthorship W3007702308A5029041782 @default.
- W3007702308 hasAuthorship W3007702308A5066292409 @default.
- W3007702308 hasConcept C104317684 @default.
- W3007702308 hasConcept C141231307 @default.
- W3007702308 hasConcept C54355233 @default.
- W3007702308 hasConcept C6929976 @default.
- W3007702308 hasConcept C70721500 @default.
- W3007702308 hasConcept C86803240 @default.
- W3007702308 hasConceptScore W3007702308C104317684 @default.
- W3007702308 hasConceptScore W3007702308C141231307 @default.
- W3007702308 hasConceptScore W3007702308C54355233 @default.
- W3007702308 hasConceptScore W3007702308C6929976 @default.
- W3007702308 hasConceptScore W3007702308C70721500 @default.
- W3007702308 hasConceptScore W3007702308C86803240 @default.
- W3007702308 hasFunder F4320320709 @default.
- W3007702308 hasFunder F4320334971 @default.
- W3007702308 hasIssue "4" @default.
- W3007702308 hasLocation W30077023081 @default.
- W3007702308 hasOpenAccess W3007702308 @default.
- W3007702308 hasPrimaryLocation W30077023081 @default.
- W3007702308 hasRelatedWork W1991523530 @default.
- W3007702308 hasRelatedWork W2002128513 @default.
- W3007702308 hasRelatedWork W2020824267 @default.
- W3007702308 hasRelatedWork W2030640333 @default.
- W3007702308 hasRelatedWork W2031436818 @default.
- W3007702308 hasRelatedWork W2057739827 @default.
- W3007702308 hasRelatedWork W2075354549 @default.
- W3007702308 hasRelatedWork W2119103177 @default.
- W3007702308 hasRelatedWork W3164573509 @default.
- W3007702308 hasRelatedWork W2092874662 @default.
- W3007702308 hasVolume "9" @default.
- W3007702308 isParatext "false" @default.
- W3007702308 isRetracted "false" @default.
- W3007702308 magId "3007702308" @default.
- W3007702308 workType "article" @default.