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- W3007730235 endingPage "70" @default.
- W3007730235 startingPage "53" @default.
- W3007730235 abstract "Colorectal carcinoma (CRC) is an heterogeneous disease in which different genetic alterations play a role in its pathogenesis and progression and offer potential for therapeutic intervention. The research on predictive biomarkers in metastatic CRC (mCRC) mainly focused on the identification of biomarkers of response or resistance to anti-epidermal growth factor receptor monoclonal antibodies. In this respect, international guidelines suggest testing mCRC patients only for KRAS, NRAS and BRAF mutations and for microsatellite instability. However, the use of novel testing methods is raising relevant issue related to these biomarkers, such as the presence of sub-clonal RAS mutations or the clinical interpretation of rare no-V600 BRAF variants. In addition, a number of novel biomarkers is emerging from recent studies including amplification of ERBB2, mutations in ERBB2, MAP2K1 and NF1 and rearrangements of ALK, ROS1, NTRK and RET. Mutations in POLE and the levels of tumor mutation burden also appear as possible biomarkers of response to immunotherapy in CRC. Finally, the consensus molecular subtypes classification of CRC based on gene expression profiling has prognostic and predictive implications. Integration of all these information will be likely necessary in the next future in order to improve precision/personalized medicine in mCRC patients." @default.
- W3007730235 created "2020-03-06" @default.
- W3007730235 creator A5003014678 @default.
- W3007730235 creator A5004893670 @default.
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- W3007730235 creator A5036367394 @default.
- W3007730235 creator A5066249862 @default.
- W3007730235 creator A5080457933 @default.
- W3007730235 date "2020-02-29" @default.
- W3007730235 modified "2023-10-14" @default.
- W3007730235 title "Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma" @default.
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