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- W3007784078 abstract "Bovine S100 G (calbindin D9k, small Ca2+-binding protein of the EF-hand superfamily) is considered as a calcium buffer protein; i.e., the binding of Ca2+ practically does not change its general conformation. A set of experimental approaches has been used to study structural properties of apo- and Ca2+-loaded forms of mouse S100 G (81.4% identity in amino acid sequence with bovine S100 G). This analysis revealed that, in contrast to bovine S100 G, the removal of calcium ions increases α-helices content of mouse S100 G protein and enhances its accessibility to digestion by α-chymotrypsin. Furthermore, mouse apo-S100 G is characterized by a decreased surface hydrophobicity and reduced tendency for oligomerization. Such behavior is typical of calcium sensor proteins. Apo-state of mouse S100 G still has rather compact structure, which can be cooperatively unfolded by temperature and GdnHCl. Computational analysis of amino acid sequences of S100 G proteins shows that these proteins could be in a disordered state upon a removal of the bound calcium ions. The experimental data show that, although mouse apo-S100 G is flexible compared to the Ca2+-loaded state, the apo-form is not completely disordered and preserves some cooperatively meting structure. The origin of the unexpectedly high stability of mouse S100 G can be rationalized by an exceptionally strong association of its N- and C-terminal parts containing the EF-hands I and II, respectively." @default.
- W3007784078 created "2020-03-06" @default.
- W3007784078 creator A5002739207 @default.
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- W3007784078 creator A5083199032 @default.
- W3007784078 creator A5037742940 @default.
- W3007784078 date "2020-05-01" @default.
- W3007784078 modified "2023-10-18" @default.
- W3007784078 title "Mouse S100G protein exhibits properties characteristic of a calcium sensor" @default.
- W3007784078 cites W1495475575 @default.
- W3007784078 cites W1521958691 @default.
- W3007784078 cites W1524492065 @default.
- W3007784078 cites W1566619188 @default.
- W3007784078 cites W1599096372 @default.
- W3007784078 cites W1660937480 @default.
- W3007784078 cites W1720678970 @default.
- W3007784078 cites W1788894661 @default.
- W3007784078 cites W1792685479 @default.
- W3007784078 cites W184793376 @default.
- W3007784078 cites W1964069614 @default.
- W3007784078 cites W1964944514 @default.
- W3007784078 cites W1966626972 @default.
- W3007784078 cites W1967060390 @default.
- W3007784078 cites W1969765265 @default.
- W3007784078 cites W1974580208 @default.
- W3007784078 cites W1975121208 @default.
- W3007784078 cites W1980125832 @default.
- W3007784078 cites W1980759649 @default.
- W3007784078 cites W1981140677 @default.
- W3007784078 cites W1981264339 @default.
- W3007784078 cites W1983639468 @default.
- W3007784078 cites W1998813486 @default.
- W3007784078 cites W1998826717 @default.
- W3007784078 cites W2001297798 @default.
- W3007784078 cites W2003345560 @default.
- W3007784078 cites W2008662678 @default.
- W3007784078 cites W2010243889 @default.
- W3007784078 cites W2012646527 @default.
- W3007784078 cites W2012656208 @default.
- W3007784078 cites W2014776147 @default.
- W3007784078 cites W2016756421 @default.
- W3007784078 cites W2017370679 @default.
- W3007784078 cites W2017962480 @default.
- W3007784078 cites W2019140289 @default.
- W3007784078 cites W2019517474 @default.
- W3007784078 cites W2022160549 @default.
- W3007784078 cites W2022987595 @default.
- W3007784078 cites W2024661068 @default.
- W3007784078 cites W2028001817 @default.
- W3007784078 cites W2034373769 @default.
- W3007784078 cites W2037198241 @default.
- W3007784078 cites W2045252643 @default.
- W3007784078 cites W2046535023 @default.
- W3007784078 cites W2049476357 @default.
- W3007784078 cites W2050341653 @default.
- W3007784078 cites W2051227373 @default.
- W3007784078 cites W2054159684 @default.
- W3007784078 cites W2055460314 @default.
- W3007784078 cites W2057545775 @default.
- W3007784078 cites W2066749848 @default.
- W3007784078 cites W2077961389 @default.
- W3007784078 cites W2079851562 @default.
- W3007784078 cites W2080178091 @default.
- W3007784078 cites W2082855639 @default.
- W3007784078 cites W2084797262 @default.
- W3007784078 cites W2087751900 @default.
- W3007784078 cites W2093505872 @default.
- W3007784078 cites W2093653062 @default.
- W3007784078 cites W2099971546 @default.
- W3007784078 cites W2101953406 @default.
- W3007784078 cites W2102025585 @default.
- W3007784078 cites W2102701612 @default.
- W3007784078 cites W2102818658 @default.
- W3007784078 cites W2115190629 @default.
- W3007784078 cites W2119693327 @default.
- W3007784078 cites W2124052876 @default.
- W3007784078 cites W2124706727 @default.
- W3007784078 cites W2126551164 @default.
- W3007784078 cites W2127152209 @default.
- W3007784078 cites W2127650225 @default.
- W3007784078 cites W2128413613 @default.
- W3007784078 cites W2132926880 @default.
- W3007784078 cites W2135600128 @default.
- W3007784078 cites W2136712400 @default.
- W3007784078 cites W2139183106 @default.
- W3007784078 cites W2143067079 @default.
- W3007784078 cites W2143399071 @default.
- W3007784078 cites W2145538573 @default.
- W3007784078 cites W2146637813 @default.
- W3007784078 cites W2148284163 @default.
- W3007784078 cites W2150017038 @default.
- W3007784078 cites W2152896929 @default.
- W3007784078 cites W2156407548 @default.
- W3007784078 cites W2156465034 @default.
- W3007784078 cites W2156678798 @default.
- W3007784078 cites W2160645453 @default.