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- W3007785622 abstract "Abstract The aldehyde derivatives of 1,3‐dipropyl xanthines as described in this paper, constitutes a new series of selective adenosine ligands displaying bronchospasmolytic activity. The effect of substitution at third‐ and fourth‐position of 8‐phenyl xanthine has also been taken into consideration. The synthesized compounds showed varying binding affinities at different adenosine receptor subtypes (A 1 , A 2A , A 2B , and A 3 ) and also good in vivo bronchospasmolytic activity against histamine aerosol‐induced asthma in guinea pigs. Most of the compounds showed maximum affinity toward the A 2A receptor subtype. The monosubstituted 3‐aminoalkoxyl 8‐phenyl xanthine with a aminodiethyl moiety (compound 12e ) was found to be most potent A 2A adenosine receptor ligand ( K i = 0.036 µM) followed by disubstituted 4‐aminoalkoxyl‐3‐methoxy‐8‐phenyl xanthine ( K i = 0.050 µM) (compound 10a )." @default.
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- W3007785622 date "2020-03-13" @default.
- W3007785622 modified "2023-10-10" @default.
- W3007785622 title "Bronchospasmolytic activity and adenosine receptor binding of some newer 1,3‐dipropyl‐8‐phenyl substituted xanthine derivatives" @default.
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- W3007785622 doi "https://doi.org/10.1111/cbdd.13673" @default.
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