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• W3007795514 startingPage "837" @default.
• W3007795514 abstract "Transcription factor (TF)-based metabolite detection mainly depends on TF-regulated gene expression in cells. From TF activation to gene transcription and translation, the signal travels a relatively long way before it is received. Here, we propose a TF-splinting duplex DNA nanoswitch to detect metabolites. We show its feasibility using tryptophan repressor (TrpR) to detect l-tryptophan as a model. The assay has been optimized and characterized after obtaining a proof of concept, and the detection of l-tryptophan in complex biological samples is feasible. Unlike an equivalent gene expression approach, the whole process is a single-step, enzyme-free, and signal-on method. It can be completed within 20 min. This proposed TF-splinting duplex has the potential to be applied to the quick and convenient detection of other metabolites or even TFs." @default.
• W3007795514 created "2020-03-06" @default.
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• W3007795514 date "2020-02-25" @default.
• W3007795514 modified "2023-10-15" @default.
• W3007795514 title "A Strategy Employing a TF-Splinting Duplex Nanoswitch to Achieve Single-Step, Enzyme-Free, Signal-On Detection of <scp>l</scp>-Tryptophan" @default.
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• W3007795514 doi "https://doi.org/10.1021/acssensors.0c00002" @default.
• W3007795514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32096406" @default.
• W3007795514 hasPublicationYear "2020" @default.
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