FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007862011> ?p ?o ?g. }

• W3007862011 endingPage "60" @default.
• W3007862011 startingPage "52" @default.
• W3007862011 abstract "Although Tanshinone IIA (Tan IIA) has been associated with inflammation, oxidative stress and apoptosis, the effects of Tan IIA on lung blast injury remain uncertain. In this study, we explored the effects of Tan IIA on lung blast injury, studied its possible molecular mechanisms. Fifty C57BL/6 mice were randomly divided into the control, blast, blast + Tan IIA, blast + LY294002 (a PI3K inhibitor), or blast + Tan IIA + LY294002 groups. Serum and lung samples were collected 48 h after blast injury. The data showed that Tan IIA significantly inhibited blast-induced increases in the lung weight/body weight and wet/dry (W/D) weight ratios, decreased the CD44−and CD163-positive inflammatory cell infiltration in the lungs, reduced the IL-1β, TNF-α and IL-6 expression, and enhanced IL-10 expression. Tan IIA also significantly alleviated the increases in MDA5 and IRE-a and the decrease in SOD-1 and reversed the low Bcl-2 expression and the high Bax and Caspase-3 expressions. Additionally, Tan IIA significantly decreased p-PI3K and p-Akt expression and increased p-FoxO1 expression. More importantly, both LY294002 and Tan IIA pretreatment markedly protected against blast-induced inflammation, oxidative stress and apoptosis in lung blast injury. These results suggest that Tan IIA protects against lung blast injury, which may be partly mediated by inhibiting the PI3K/Akt/FoxO1 signaling pathway." @default.
• W3007862011 created "2020-03-06" @default.
• W3007862011 creator A5000653833 @default.
• W3007862011 creator A5016219123 @default.
• W3007862011 creator A5020415315 @default.
• W3007862011 creator A5028386179 @default.
• W3007862011 creator A5041300196 @default.
• W3007862011 creator A5047417366 @default.
• W3007862011 creator A5056579558 @default.
• W3007862011 creator A5060002817 @default.
• W3007862011 creator A5077163190 @default.
• W3007862011 creator A5077860517 @default.
• W3007862011 creator A5081990902 @default.
• W3007862011 date "2020-05-01" @default.
• W3007862011 modified "2023-09-28" @default.
• W3007862011 title "Tanshinone IIA alleviates blast-induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway" @default.
• W3007862011 cites W1994947268 @default.
• W3007862011 cites W2007955802 @default.
• W3007862011 cites W2014260547 @default.
• W3007862011 cites W2034242967 @default.
• W3007862011 cites W2042996328 @default.
• W3007862011 cites W2077406501 @default.
• W3007862011 cites W2154744341 @default.
• W3007862011 cites W2252628367 @default.
• W3007862011 cites W2321424543 @default.
• W3007862011 cites W2321586352 @default.
• W3007862011 cites W2337937250 @default.
• W3007862011 cites W2417833782 @default.
• W3007862011 cites W2520522314 @default.
• W3007862011 cites W2575762489 @default.
• W3007862011 cites W2738584311 @default.
• W3007862011 cites W2765245679 @default.
• W3007862011 cites W2774917626 @default.
• W3007862011 cites W2802143380 @default.
• W3007862011 cites W2807852344 @default.
• W3007862011 cites W2831668599 @default.
• W3007862011 cites W2886143607 @default.
• W3007862011 cites W2887898462 @default.
• W3007862011 cites W2890656357 @default.
• W3007862011 cites W2892548826 @default.
• W3007862011 cites W2893765020 @default.
• W3007862011 cites W2903429404 @default.
• W3007862011 cites W2903553774 @default.
• W3007862011 cites W2903992563 @default.
• W3007862011 cites W2905469423 @default.
• W3007862011 cites W2916298628 @default.
• W3007862011 cites W2917448846 @default.
• W3007862011 doi "https://doi.org/10.1016/j.freeradbiomed.2020.02.032" @default.
• W3007862011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32131025" @default.
• W3007862011 hasPublicationYear "2020" @default.
• W3007862011 type Work @default.
• W3007862011 sameAs 3007862011 @default.
• W3007862011 citedByCount "22" @default.
• W3007862011 countsByYear W30078620112020 @default.
• W3007862011 countsByYear W30078620112021 @default.
• W3007862011 countsByYear W30078620112022 @default.
• W3007862011 countsByYear W30078620112023 @default.
• W3007862011 crossrefType "journal-article" @default.
• W3007862011 hasAuthorship W3007862011A5000653833 @default.
• W3007862011 hasAuthorship W3007862011A5016219123 @default.
• W3007862011 hasAuthorship W3007862011A5020415315 @default.
• W3007862011 hasAuthorship W3007862011A5028386179 @default.
• W3007862011 hasAuthorship W3007862011A5041300196 @default.
• W3007862011 hasAuthorship W3007862011A5047417366 @default.
• W3007862011 hasAuthorship W3007862011A5056579558 @default.
• W3007862011 hasAuthorship W3007862011A5060002817 @default.
• W3007862011 hasAuthorship W3007862011A5077163190 @default.
• W3007862011 hasAuthorship W3007862011A5077860517 @default.
• W3007862011 hasAuthorship W3007862011A5081990902 @default.
• W3007862011 hasConcept C134018914 @default.
• W3007862011 hasConcept C181199279 @default.
• W3007862011 hasConcept C185592680 @default.
• W3007862011 hasConcept C190283241 @default.
• W3007862011 hasConcept C203014093 @default.
• W3007862011 hasConcept C2776151105 @default.
• W3007862011 hasConcept C2776912716 @default.
• W3007862011 hasConcept C2776914184 @default.
• W3007862011 hasConcept C2777622882 @default.
• W3007862011 hasConcept C2779385521 @default.
• W3007862011 hasConcept C55493867 @default.
• W3007862011 hasConcept C71924100 @default.
• W3007862011 hasConcept C75217442 @default.
• W3007862011 hasConcept C86554907 @default.
• W3007862011 hasConceptScore W3007862011C134018914 @default.
• W3007862011 hasConceptScore W3007862011C181199279 @default.
• W3007862011 hasConceptScore W3007862011C185592680 @default.
• W3007862011 hasConceptScore W3007862011C190283241 @default.
• W3007862011 hasConceptScore W3007862011C203014093 @default.
• W3007862011 hasConceptScore W3007862011C2776151105 @default.
• W3007862011 hasConceptScore W3007862011C2776912716 @default.
• W3007862011 hasConceptScore W3007862011C2776914184 @default.
• W3007862011 hasConceptScore W3007862011C2777622882 @default.
• W3007862011 hasConceptScore W3007862011C2779385521 @default.
• W3007862011 hasConceptScore W3007862011C55493867 @default.
• W3007862011 hasConceptScore W3007862011C71924100 @default.
• W3007862011 hasConceptScore W3007862011C75217442 @default.
• W3007862011 hasConceptScore W3007862011C86554907 @default.
• W3007862011 hasLocation W30078620111 @default.

• next