FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007870834> ?p ?o ?g. }

• W3007870834 endingPage "e692" @default.
• W3007870834 startingPage "e692" @default.
• W3007870834 abstract "Objective Prognosis of stroke is negatively affected by complications, in particular stroke-associated pneumonia (SAP). We hypothesized that inflammatory and stress biomarkers predict SAP during hospitalization and outcome 3 months after stroke. Methods We pooled the clinical data of 2 acute stroke studies with identical assessment: the STRoke Adverse outcome is associated WIth NoSoKomial Infections (STRAWINSKI) and PREDICT studies. Measurement of biomarkers (ultrasensitive procalcitonin [PCTus]; midregional pro-adrenomedullin; midregional pro-atrial natriuretic peptide [MRproANP]; ultrasensitive copeptin [CPus]; C-terminal pro-endothelin) was performed from serum samples drawn on the first 4 days of hospital admission. Results The combined cohort consists of 573 cases with available backup samples to perform the analysis. SAP was associated with increased admission and maximum levels of all biomarkers. Furthermore, all biomarkers were associated with death and correlated with functional outcome 3 months after stroke. The multivariate logistic regression model retained ultrasensitive CPus and PCTus beyond clinical risk factors for predicting SAP, improving the receiver operating characteristic area under the curve (AUC) from 0.837 to 0.876. In contrast, the biomarkers did not improve the prediction of death and functional outcome in the multivariate model. Cardioembolic strokes were significantly associated with higher values of all biomarkers, whereas discrimination was best for MRproANP (AUC = 0.811 for maximum value). Conclusions The tested biomarkers are associated with SAP and poor functional outcome. However, these biomarkers only slightly improve prediction of SAP and do not improve long-term outcome prediction over clinical parameters. MRproANP showed the best discrimination for identifying cardioembolic stroke, warranting further studies to confirm our finding. Clinical trial registration clinicaltrials.gov NCT01264549 and NCT01079728 ." @default.
• W3007870834 created "2020-03-06" @default.
• W3007870834 creator A5012562356 @default.
• W3007870834 creator A5020460474 @default.
• W3007870834 creator A5043607239 @default.
• W3007870834 creator A5048009605 @default.
• W3007870834 creator A5065638265 @default.
• W3007870834 creator A5069451422 @default.
• W3007870834 creator A5090957908 @default.
• W3007870834 date "2020-02-25" @default.
• W3007870834 modified "2023-10-14" @default.
• W3007870834 title "Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke" @default.
• W3007870834 cites W1965099608 @default.
• W3007870834 cites W2009553854 @default.
• W3007870834 cites W2009858151 @default.
• W3007870834 cites W2022943665 @default.
• W3007870834 cites W2023470451 @default.
• W3007870834 cites W2053216945 @default.
• W3007870834 cites W2056793603 @default.
• W3007870834 cites W2066706020 @default.
• W3007870834 cites W2077909112 @default.
• W3007870834 cites W2088794031 @default.
• W3007870834 cites W2103066461 @default.
• W3007870834 cites W2140430950 @default.
• W3007870834 cites W2162769732 @default.
• W3007870834 cites W2403797838 @default.
• W3007870834 cites W2418776990 @default.
• W3007870834 cites W2531419784 @default.
• W3007870834 cites W2557264708 @default.
• W3007870834 cites W2606564419 @default.
• W3007870834 cites W2608403661 @default.
• W3007870834 cites W2746701399 @default.
• W3007870834 cites W2912186209 @default.
• W3007870834 cites W2920221346 @default.
• W3007870834 cites W2920372052 @default.
• W3007870834 cites W4362179036 @default.
• W3007870834 doi "https://doi.org/10.1212/nxi.0000000000000692" @default.
• W3007870834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7051196" @default.
• W3007870834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32098866" @default.
• W3007870834 hasPublicationYear "2020" @default.
• W3007870834 type Work @default.
• W3007870834 sameAs 3007870834 @default.
• W3007870834 citedByCount "24" @default.
• W3007870834 countsByYear W30078708342020 @default.
• W3007870834 countsByYear W30078708342021 @default.
• W3007870834 countsByYear W30078708342022 @default.
• W3007870834 countsByYear W30078708342023 @default.
• W3007870834 crossrefType "journal-article" @default.
• W3007870834 hasAuthorship W3007870834A5012562356 @default.
• W3007870834 hasAuthorship W3007870834A5020460474 @default.
• W3007870834 hasAuthorship W3007870834A5043607239 @default.
• W3007870834 hasAuthorship W3007870834A5048009605 @default.
• W3007870834 hasAuthorship W3007870834A5065638265 @default.
• W3007870834 hasAuthorship W3007870834A5069451422 @default.
• W3007870834 hasAuthorship W3007870834A5090957908 @default.
• W3007870834 hasBestOaLocation W30078708341 @default.
• W3007870834 hasConcept C10936531 @default.
• W3007870834 hasConcept C126322002 @default.
• W3007870834 hasConcept C127413603 @default.
• W3007870834 hasConcept C151956035 @default.
• W3007870834 hasConcept C177713679 @default.
• W3007870834 hasConcept C185592680 @default.
• W3007870834 hasConcept C2776370428 @default.
• W3007870834 hasConcept C2777914695 @default.
• W3007870834 hasConcept C2778384902 @default.
• W3007870834 hasConcept C2779311642 @default.
• W3007870834 hasConcept C2780645631 @default.
• W3007870834 hasConcept C2781197716 @default.
• W3007870834 hasConcept C55493867 @default.
• W3007870834 hasConcept C58471807 @default.
• W3007870834 hasConcept C71924100 @default.
• W3007870834 hasConcept C72563966 @default.
• W3007870834 hasConcept C76318530 @default.
• W3007870834 hasConcept C78519656 @default.
• W3007870834 hasConceptScore W3007870834C10936531 @default.
• W3007870834 hasConceptScore W3007870834C126322002 @default.
• W3007870834 hasConceptScore W3007870834C127413603 @default.
• W3007870834 hasConceptScore W3007870834C151956035 @default.
• W3007870834 hasConceptScore W3007870834C177713679 @default.
• W3007870834 hasConceptScore W3007870834C185592680 @default.
• W3007870834 hasConceptScore W3007870834C2776370428 @default.
• W3007870834 hasConceptScore W3007870834C2777914695 @default.
• W3007870834 hasConceptScore W3007870834C2778384902 @default.
• W3007870834 hasConceptScore W3007870834C2779311642 @default.
• W3007870834 hasConceptScore W3007870834C2780645631 @default.
• W3007870834 hasConceptScore W3007870834C2781197716 @default.
• W3007870834 hasConceptScore W3007870834C55493867 @default.
• W3007870834 hasConceptScore W3007870834C58471807 @default.
• W3007870834 hasConceptScore W3007870834C71924100 @default.
• W3007870834 hasConceptScore W3007870834C72563966 @default.
• W3007870834 hasConceptScore W3007870834C76318530 @default.
• W3007870834 hasConceptScore W3007870834C78519656 @default.
• W3007870834 hasIssue "3" @default.
• W3007870834 hasLocation W30078708341 @default.
• W3007870834 hasLocation W30078708342 @default.
• W3007870834 hasLocation W30078708343 @default.
• W3007870834 hasLocation W30078708344 @default.
• W3007870834 hasOpenAccess W3007870834 @default.

• next