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- W3007880151 abstract "Negative symptoms of schizophrenia are debilitating and chronic in nature, are difficult to treat, and contribute to poor functional outcomes. Motivational deficits are a core negative symptom and may involve alterations in reward processing, which involve subcortical regions such as the basal ganglia. More specifically, dopamine-rich regions like the ventral striatum, have been implicated in these reward-processing deficits. Inflammation is one mechanism that may underlie negative symptoms, and specifically motivational deficits, via the effects of inflammatory cytokines on the basal ganglia. Previous work has demonstrated that inflammatory stimuli decrease neural activity in the ventral striatum and decrease connectivity in reward-relevant neural circuitry. The immune system has been shown to be involved in the pathophysiology of schizophrenia, and inflammatory cytokines have been shown to be altered in patients with the disorder. This paper reviews the literature on associations between inflammatory markers and negative symptoms of schizophrenia as well as the role of anti-inflammatory drugs to target negative symptoms. We also review the literature on the role of inflammation and reward processing deficits in both healthy controls and individuals with depression. We use the literature on inflammation and depression as a basis for a model that explores potential mechanisms responsible for inflammation modulating certain aspects of negative symptoms in patients with schizophrenia. This approach may offer novel targets to treat these symptoms of the disorder that are significant barriers to functional recovery and do not respond well to available antipsychotic medications." @default.
- W3007880151 created "2020-03-06" @default.
- W3007880151 creator A5008411031 @default.
- W3007880151 creator A5010706583 @default.
- W3007880151 date "2020-02-20" @default.
- W3007880151 modified "2023-09-30" @default.
- W3007880151 title "Inflammation and Negative Symptoms of Schizophrenia: Implications for Reward Processing and Motivational Deficits" @default.
- W3007880151 cites W1219461777 @default.
- W3007880151 cites W147937724 @default.
- W3007880151 cites W1489146791 @default.
- W3007880151 cites W1763821615 @default.
- W3007880151 cites W1881742737 @default.
- W3007880151 cites W1901464946 @default.
- W3007880151 cites W1903805787 @default.
- W3007880151 cites W1959147886 @default.
- W3007880151 cites W1966618733 @default.
- W3007880151 cites W1969833165 @default.
- W3007880151 cites W1976431364 @default.
- W3007880151 cites W1977026805 @default.
- W3007880151 cites W1977465442 @default.
- W3007880151 cites W1980302503 @default.
- W3007880151 cites W1985329135 @default.
- W3007880151 cites W1986187532 @default.
- W3007880151 cites W1987949359 @default.
- W3007880151 cites W1989199068 @default.
- W3007880151 cites W1990532967 @default.
- W3007880151 cites W1994829259 @default.
- W3007880151 cites W1997291002 @default.
- W3007880151 cites W2001941062 @default.
- W3007880151 cites W2005933475 @default.
- W3007880151 cites W200959462 @default.
- W3007880151 cites W2010407531 @default.
- W3007880151 cites W2010945210 @default.
- W3007880151 cites W2011355421 @default.
- W3007880151 cites W2013514700 @default.
- W3007880151 cites W2014596655 @default.
- W3007880151 cites W2015054993 @default.
- W3007880151 cites W2015656459 @default.
- W3007880151 cites W2022412147 @default.
- W3007880151 cites W2022433310 @default.
- W3007880151 cites W2023504580 @default.
- W3007880151 cites W2024908874 @default.
- W3007880151 cites W2026508141 @default.
- W3007880151 cites W2027578103 @default.
- W3007880151 cites W2029856455 @default.
- W3007880151 cites W2031619354 @default.
- W3007880151 cites W2036480935 @default.
- W3007880151 cites W2040789766 @default.
- W3007880151 cites W2041951497 @default.
- W3007880151 cites W2042755650 @default.
- W3007880151 cites W2047073785 @default.
- W3007880151 cites W2050353431 @default.
- W3007880151 cites W2052445433 @default.
- W3007880151 cites W2053020615 @default.
- W3007880151 cites W2054475627 @default.
- W3007880151 cites W2054501409 @default.
- W3007880151 cites W2057688664 @default.
- W3007880151 cites W2057690098 @default.
- W3007880151 cites W2059416963 @default.
- W3007880151 cites W2060913403 @default.
- W3007880151 cites W2063902973 @default.
- W3007880151 cites W2064799289 @default.
- W3007880151 cites W2064885604 @default.
- W3007880151 cites W2064979740 @default.
- W3007880151 cites W2068011539 @default.
- W3007880151 cites W2068772097 @default.
- W3007880151 cites W2069604660 @default.
- W3007880151 cites W2070023870 @default.
- W3007880151 cites W2071815275 @default.
- W3007880151 cites W2073579715 @default.
- W3007880151 cites W2073806182 @default.
- W3007880151 cites W2074669819 @default.
- W3007880151 cites W2075199575 @default.
- W3007880151 cites W2077117413 @default.
- W3007880151 cites W2082483237 @default.
- W3007880151 cites W2082642969 @default.
- W3007880151 cites W2084331056 @default.
- W3007880151 cites W2086366128 @default.
- W3007880151 cites W2089159998 @default.
- W3007880151 cites W2089521828 @default.
- W3007880151 cites W2091259554 @default.
- W3007880151 cites W2094099090 @default.
- W3007880151 cites W2094404268 @default.
- W3007880151 cites W2095651675 @default.
- W3007880151 cites W2096192353 @default.
- W3007880151 cites W2096987707 @default.
- W3007880151 cites W2098108268 @default.
- W3007880151 cites W2101357408 @default.
- W3007880151 cites W2102181001 @default.
- W3007880151 cites W2102225001 @default.
- W3007880151 cites W2103636917 @default.
- W3007880151 cites W2105608590 @default.
- W3007880151 cites W2106116736 @default.
- W3007880151 cites W2109059823 @default.
- W3007880151 cites W2110463517 @default.
- W3007880151 cites W2112334970 @default.
- W3007880151 cites W2113345170 @default.
- W3007880151 cites W2115624750 @default.
- W3007880151 cites W2118755615 @default.
- W3007880151 cites W2121313171 @default.