FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007886688> ?p ?o ?g. }

• W3007886688 endingPage "43" @default.
• W3007886688 startingPage "32" @default.
• W3007886688 abstract "Abstract Background CDGSH iron sulfur domain-containing protein 1 (CISD-1) belongs to the CISD protein family that is evolutionary conserved across different species. In mammals, CISD-1 protein has been implicated in diseases such as cancers and diabetes. As a tractable model organism to study disease-associated proteins, we employed Caenorhabditis elegans in this study with an aim to establish a model for interrogating the functional relevance of CISD-1 in human metabolic conditions. Methods We first bioinformatically identified the human Cisd-1 homologue in worms. We then employed N2 wild-type and cisd-1(tm4993) mutant to investigate the consequences of CISD-1 loss-of-function on: 1) the expression pattern of CISD-1, 2) mitochondrial morphology pattern, 3) mitochondrial function and bioenergetics, and 4) the effects of anti-diabetes drugs. Results We first identified C. elegans W02B12.15 gene as the human Cisd-1 homologous gene, and pinpointed the localization of CISD-1 to the outer membrane of mitochondria. As compared with the N2 wild-type worm, cisd-1(tm4993) mutant exhibited a higher proportion of hyperfused form of mitochondria. This structural abnormality was associated with the generation of higher levels of ROS and mitochondrial superoxide but lower ATP. These physiological changes in mutants did not result in discernable effects on animal motility and lifespan. Moreover, the amount of glucose in N2 wild-type worms treated with troglitazone and pioglitazone, derivatives of TZD, was reduced to a comparable level as in the mutant animals. Conclusions By focusing on the Cisd-1 gene, our study established a C. elegans genetic system suitable for modeling human diabetes-related diseases." @default.
• W3007886688 created "2020-03-06" @default.
• W3007886688 creator A5001414258 @default.
• W3007886688 creator A5011587426 @default.
• W3007886688 creator A5017574412 @default.
• W3007886688 creator A5050492618 @default.
• W3007886688 creator A5060816367 @default.
• W3007886688 creator A5072772526 @default.
• W3007886688 creator A5088084981 @default.
• W3007886688 date "2020-02-01" @default.
• W3007886688 modified "2023-10-17" @default.
• W3007886688 title "Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans" @default.
• W3007886688 cites W1518241034 @default.
• W3007886688 cites W1556017032 @default.
• W3007886688 cites W1581412826 @default.
• W3007886688 cites W1944127002 @default.
• W3007886688 cites W1973973036 @default.
• W3007886688 cites W1983890824 @default.
• W3007886688 cites W1985806842 @default.
• W3007886688 cites W1996384706 @default.
• W3007886688 cites W2006178088 @default.
• W3007886688 cites W2010802040 @default.
• W3007886688 cites W2022758805 @default.
• W3007886688 cites W2039402710 @default.
• W3007886688 cites W2039552811 @default.
• W3007886688 cites W2041757368 @default.
• W3007886688 cites W2047591801 @default.
• W3007886688 cites W2050915787 @default.
• W3007886688 cites W2060262332 @default.
• W3007886688 cites W2061723782 @default.
• W3007886688 cites W2073746011 @default.
• W3007886688 cites W2086531898 @default.
• W3007886688 cites W2116048591 @default.
• W3007886688 cites W2116472408 @default.
• W3007886688 cites W2144377119 @default.
• W3007886688 cites W2170425200 @default.
• W3007886688 cites W2171937090 @default.
• W3007886688 cites W2174118934 @default.
• W3007886688 cites W2293782839 @default.
• W3007886688 cites W2332381550 @default.
• W3007886688 cites W2403578638 @default.
• W3007886688 cites W2510363148 @default.
• W3007886688 cites W2546215880 @default.
• W3007886688 cites W2552194858 @default.
• W3007886688 cites W2588505129 @default.
• W3007886688 cites W2617857661 @default.
• W3007886688 cites W2741481561 @default.
• W3007886688 cites W2753466611 @default.
• W3007886688 cites W2768764622 @default.
• W3007886688 cites W2779852721 @default.
• W3007886688 cites W2787930551 @default.
• W3007886688 cites W2799961749 @default.
• W3007886688 cites W2966296041 @default.
• W3007886688 doi "https://doi.org/10.1016/j.bj.2019.07.009" @default.
• W3007886688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7090286" @default.
• W3007886688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32200954" @default.
• W3007886688 hasPublicationYear "2020" @default.
• W3007886688 type Work @default.
• W3007886688 sameAs 3007886688 @default.
• W3007886688 citedByCount "9" @default.
• W3007886688 countsByYear W30078866882020 @default.
• W3007886688 countsByYear W30078866882021 @default.
• W3007886688 countsByYear W30078866882022 @default.
• W3007886688 countsByYear W30078866882023 @default.
• W3007886688 crossrefType "journal-article" @default.
• W3007886688 hasAuthorship W3007886688A5001414258 @default.
• W3007886688 hasAuthorship W3007886688A5011587426 @default.
• W3007886688 hasAuthorship W3007886688A5017574412 @default.
• W3007886688 hasAuthorship W3007886688A5050492618 @default.
• W3007886688 hasAuthorship W3007886688A5060816367 @default.
• W3007886688 hasAuthorship W3007886688A5072772526 @default.
• W3007886688 hasAuthorship W3007886688A5088084981 @default.
• W3007886688 hasBestOaLocation W30078866881 @default.
• W3007886688 hasConcept C104317684 @default.
• W3007886688 hasConcept C178790620 @default.
• W3007886688 hasConcept C185592680 @default.
• W3007886688 hasConcept C2778944004 @default.
• W3007886688 hasConcept C2779564974 @default.
• W3007886688 hasConcept C28859421 @default.
• W3007886688 hasConcept C3675279 @default.
• W3007886688 hasConcept C518881349 @default.
• W3007886688 hasConcept C55493867 @default.
• W3007886688 hasConcept C86803240 @default.
• W3007886688 hasConcept C95444343 @default.
• W3007886688 hasConceptScore W3007886688C104317684 @default.
• W3007886688 hasConceptScore W3007886688C178790620 @default.
• W3007886688 hasConceptScore W3007886688C185592680 @default.
• W3007886688 hasConceptScore W3007886688C2778944004 @default.
• W3007886688 hasConceptScore W3007886688C2779564974 @default.
• W3007886688 hasConceptScore W3007886688C28859421 @default.
• W3007886688 hasConceptScore W3007886688C3675279 @default.
• W3007886688 hasConceptScore W3007886688C518881349 @default.
• W3007886688 hasConceptScore W3007886688C55493867 @default.
• W3007886688 hasConceptScore W3007886688C86803240 @default.
• W3007886688 hasConceptScore W3007886688C95444343 @default.
• W3007886688 hasFunder F4320311687 @default.
• W3007886688 hasFunder F4320313619 @default.
• W3007886688 hasFunder F4320322795 @default.

• next