FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007892072> ?p ?o ?g. }

• W3007892072 endingPage "403" @default.
• W3007892072 startingPage "399" @default.
• W3007892072 abstract "Immune checkpoint inhibitors (ICIs) exert beneficial effects in non-small cell lung cancer (NSCLC) patients. However, ICIs are only advantageous for a limited population of NSCLC patients. Therefore to enhance their effects, combination therapies with ICIs have been developed. To identify preferable chemotherapy to combine with ICIs against lung cancer, we examined immunological effects of docetaxel compared with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). We found no difference in peripheral lymphocyte counts and ratio of their subpopulations in lung cancer patients before and after both treatments. On the other hand, plasma levels of high-mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, showed significant increase after docetaxel treatment. Furthermore, we investigated effects of HMGB1 on tumor-infiltrating immune cells obtained from surgically resected tumor tissue from NSCLC patients. When the tumor infiltrating cells were stimulated with HMGB1, CD11c+ cells showed increased expression of activation markers. These findings imply that docetaxel could be involved in anti-tumor immunity via HMGB1. Therefore docetaxel might be a candidate for combination treatment with ICIs." @default.
• W3007892072 created "2020-03-06" @default.
• W3007892072 creator A5003747920 @default.
• W3007892072 creator A5011006346 @default.
• W3007892072 creator A5024225553 @default.
• W3007892072 creator A5026633755 @default.
• W3007892072 creator A5034211195 @default.
• W3007892072 creator A5037248121 @default.
• W3007892072 creator A5039063844 @default.
• W3007892072 creator A5040981480 @default.
• W3007892072 creator A5051283453 @default.
• W3007892072 creator A5056627403 @default.
• W3007892072 creator A5066498071 @default.
• W3007892072 creator A5086026504 @default.
• W3007892072 date "2020-03-01" @default.
• W3007892072 modified "2023-10-16" @default.
• W3007892072 title "Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer" @default.
• W3007892072 cites W1480342889 @default.
• W3007892072 cites W1978845670 @default.
• W3007892072 cites W1982467804 @default.
• W3007892072 cites W1998173939 @default.
• W3007892072 cites W2104347254 @default.
• W3007892072 cites W2156353875 @default.
• W3007892072 cites W2344221521 @default.
• W3007892072 cites W2796582438 @default.
• W3007892072 cites W2805354595 @default.
• W3007892072 cites W2922124059 @default.
• W3007892072 cites W2923518308 @default.
• W3007892072 doi "https://doi.org/10.1248/bpb.b19-00702" @default.
• W3007892072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32115500" @default.
• W3007892072 hasPublicationYear "2020" @default.
• W3007892072 type Work @default.
• W3007892072 sameAs 3007892072 @default.
• W3007892072 citedByCount "10" @default.
• W3007892072 countsByYear W30078920722020 @default.
• W3007892072 countsByYear W30078920722021 @default.
• W3007892072 countsByYear W30078920722022 @default.
• W3007892072 crossrefType "journal-article" @default.
• W3007892072 hasAuthorship W3007892072A5003747920 @default.
• W3007892072 hasAuthorship W3007892072A5011006346 @default.
• W3007892072 hasAuthorship W3007892072A5024225553 @default.
• W3007892072 hasAuthorship W3007892072A5026633755 @default.
• W3007892072 hasAuthorship W3007892072A5034211195 @default.
• W3007892072 hasAuthorship W3007892072A5037248121 @default.
• W3007892072 hasAuthorship W3007892072A5039063844 @default.
• W3007892072 hasAuthorship W3007892072A5040981480 @default.
• W3007892072 hasAuthorship W3007892072A5051283453 @default.
• W3007892072 hasAuthorship W3007892072A5056627403 @default.
• W3007892072 hasAuthorship W3007892072A5066498071 @default.
• W3007892072 hasAuthorship W3007892072A5086026504 @default.
• W3007892072 hasBestOaLocation W30078920721 @default.
• W3007892072 hasConcept C101544691 @default.
• W3007892072 hasConcept C121608353 @default.
• W3007892072 hasConcept C126322002 @default.
• W3007892072 hasConcept C143998085 @default.
• W3007892072 hasConcept C170493617 @default.
• W3007892072 hasConcept C203014093 @default.
• W3007892072 hasConcept C2776256026 @default.
• W3007892072 hasConcept C2776694085 @default.
• W3007892072 hasConcept C2780545709 @default.
• W3007892072 hasConcept C2781185341 @default.
• W3007892072 hasConcept C2781190966 @default.
• W3007892072 hasConcept C2908647359 @default.
• W3007892072 hasConcept C502942594 @default.
• W3007892072 hasConcept C71924100 @default.
• W3007892072 hasConcept C8891405 @default.
• W3007892072 hasConcept C99454951 @default.
• W3007892072 hasConceptScore W3007892072C101544691 @default.
• W3007892072 hasConceptScore W3007892072C121608353 @default.
• W3007892072 hasConceptScore W3007892072C126322002 @default.
• W3007892072 hasConceptScore W3007892072C143998085 @default.
• W3007892072 hasConceptScore W3007892072C170493617 @default.
• W3007892072 hasConceptScore W3007892072C203014093 @default.
• W3007892072 hasConceptScore W3007892072C2776256026 @default.
• W3007892072 hasConceptScore W3007892072C2776694085 @default.
• W3007892072 hasConceptScore W3007892072C2780545709 @default.
• W3007892072 hasConceptScore W3007892072C2781185341 @default.
• W3007892072 hasConceptScore W3007892072C2781190966 @default.
• W3007892072 hasConceptScore W3007892072C2908647359 @default.
• W3007892072 hasConceptScore W3007892072C502942594 @default.
• W3007892072 hasConceptScore W3007892072C71924100 @default.
• W3007892072 hasConceptScore W3007892072C8891405 @default.
• W3007892072 hasConceptScore W3007892072C99454951 @default.
• W3007892072 hasIssue "3" @default.
• W3007892072 hasLocation W30078920721 @default.
• W3007892072 hasLocation W30078920722 @default.
• W3007892072 hasOpenAccess W3007892072 @default.
• W3007892072 hasPrimaryLocation W30078920721 @default.
• W3007892072 hasRelatedWork W2080820783 @default.
• W3007892072 hasRelatedWork W2085307618 @default.
• W3007892072 hasRelatedWork W2098897002 @default.
• W3007892072 hasRelatedWork W2167650070 @default.
• W3007892072 hasRelatedWork W2315587357 @default.
• W3007892072 hasRelatedWork W2336397012 @default.
• W3007892072 hasRelatedWork W2604145495 @default.
• W3007892072 hasRelatedWork W2912642934 @default.
• W3007892072 hasRelatedWork W3029039913 @default.
• W3007892072 hasRelatedWork W3032029751 @default.

• next