Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007897522> ?p ?o ?g. }
- W3007897522 endingPage "624" @default.
- W3007897522 startingPage "615" @default.
- W3007897522 abstract "Spinal cord injury (SCI) represents an extremely debilitating condition for which no efficacious treatment is available. Because spinal cord does not have satisfactory capacity for revascularization after injury, it seems to be a promising way to modulate the lesion environment by reperfusion to promote a regenerative phenotype. Although engineered scaffolds provide a platform to deliver therapeutic cells and neurotrophic factors, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells. In this study, we cocultured our fibrous porous silk scaffold (FPSS) with ADAMTS13-overexpressing human umbilical vein endothelial cells (HUVECs) in vitro and transplanted this prevascularized construct into an SCI mouse model. The prevascularized system exhibited a tube-like structure in vitro, promoted vascular infiltration and microvascular network formation after transplantation, and recruited more neural cells to the lesion site. Twenty-eight days later, behavioral analysis showed that locomotor recovery was significantly improved in treated animals compared with control animals. Taken together, our results suggest that the FPSS-HUVECs system promoted neovascularization, guided axon growth at the injury site, and improved the microenvironment. Therefore, this prevascularization system may provide a better therapeutic option for SCI." @default.
- W3007897522 created "2020-03-06" @default.
- W3007897522 creator A5001769423 @default.
- W3007897522 creator A5023674283 @default.
- W3007897522 creator A5024357752 @default.
- W3007897522 creator A5036164591 @default.
- W3007897522 creator A5044941594 @default.
- W3007897522 creator A5058016226 @default.
- W3007897522 creator A5069331768 @default.
- W3007897522 creator A5085301513 @default.
- W3007897522 date "2020-05-01" @default.
- W3007897522 modified "2023-10-16" @default.
- W3007897522 title "A Prevascularization Strategy Using Novel Fibrous Porous Silk Scaffolds for Tissue Regeneration in Mice with Spinal Cord Injury" @default.
- W3007897522 cites W1234073440 @default.
- W3007897522 cites W1591103981 @default.
- W3007897522 cites W1980352405 @default.
- W3007897522 cites W1980977837 @default.
- W3007897522 cites W1988432563 @default.
- W3007897522 cites W1990417946 @default.
- W3007897522 cites W1992781478 @default.
- W3007897522 cites W1998384354 @default.
- W3007897522 cites W2006414629 @default.
- W3007897522 cites W2006560625 @default.
- W3007897522 cites W2036122797 @default.
- W3007897522 cites W2044014818 @default.
- W3007897522 cites W2045734862 @default.
- W3007897522 cites W2067978052 @default.
- W3007897522 cites W2091107068 @default.
- W3007897522 cites W2137612350 @default.
- W3007897522 cites W2157908104 @default.
- W3007897522 cites W2163660141 @default.
- W3007897522 cites W2166607129 @default.
- W3007897522 cites W2344977712 @default.
- W3007897522 cites W2529413696 @default.
- W3007897522 cites W2545674593 @default.
- W3007897522 cites W2606400921 @default.
- W3007897522 cites W2734672213 @default.
- W3007897522 cites W2744975517 @default.
- W3007897522 cites W2759747651 @default.
- W3007897522 cites W2761603724 @default.
- W3007897522 cites W2783984100 @default.
- W3007897522 cites W2794265299 @default.
- W3007897522 cites W2902845347 @default.
- W3007897522 cites W2953573302 @default.
- W3007897522 cites W2971635645 @default.
- W3007897522 cites W4211195525 @default.
- W3007897522 doi "https://doi.org/10.1089/scd.2019.0199" @default.
- W3007897522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32085678" @default.
- W3007897522 hasPublicationYear "2020" @default.
- W3007897522 type Work @default.
- W3007897522 sameAs 3007897522 @default.
- W3007897522 citedByCount "10" @default.
- W3007897522 countsByYear W30078975222021 @default.
- W3007897522 countsByYear W30078975222022 @default.
- W3007897522 countsByYear W30078975222023 @default.
- W3007897522 crossrefType "journal-article" @default.
- W3007897522 hasAuthorship W3007897522A5001769423 @default.
- W3007897522 hasAuthorship W3007897522A5023674283 @default.
- W3007897522 hasAuthorship W3007897522A5024357752 @default.
- W3007897522 hasAuthorship W3007897522A5036164591 @default.
- W3007897522 hasAuthorship W3007897522A5044941594 @default.
- W3007897522 hasAuthorship W3007897522A5058016226 @default.
- W3007897522 hasAuthorship W3007897522A5069331768 @default.
- W3007897522 hasAuthorship W3007897522A5085301513 @default.
- W3007897522 hasBestOaLocation W30078975221 @default.
- W3007897522 hasConcept C105702510 @default.
- W3007897522 hasConcept C141071460 @default.
- W3007897522 hasConcept C142724271 @default.
- W3007897522 hasConcept C169760540 @default.
- W3007897522 hasConcept C171056886 @default.
- W3007897522 hasConcept C2778271429 @default.
- W3007897522 hasConcept C2778334475 @default.
- W3007897522 hasConcept C2779530196 @default.
- W3007897522 hasConcept C2780394083 @default.
- W3007897522 hasConcept C2780775167 @default.
- W3007897522 hasConcept C2781156865 @default.
- W3007897522 hasConcept C2911091166 @default.
- W3007897522 hasConcept C502942594 @default.
- W3007897522 hasConcept C71924100 @default.
- W3007897522 hasConcept C86803240 @default.
- W3007897522 hasConcept C95444343 @default.
- W3007897522 hasConceptScore W3007897522C105702510 @default.
- W3007897522 hasConceptScore W3007897522C141071460 @default.
- W3007897522 hasConceptScore W3007897522C142724271 @default.
- W3007897522 hasConceptScore W3007897522C169760540 @default.
- W3007897522 hasConceptScore W3007897522C171056886 @default.
- W3007897522 hasConceptScore W3007897522C2778271429 @default.
- W3007897522 hasConceptScore W3007897522C2778334475 @default.
- W3007897522 hasConceptScore W3007897522C2779530196 @default.
- W3007897522 hasConceptScore W3007897522C2780394083 @default.
- W3007897522 hasConceptScore W3007897522C2780775167 @default.
- W3007897522 hasConceptScore W3007897522C2781156865 @default.
- W3007897522 hasConceptScore W3007897522C2911091166 @default.
- W3007897522 hasConceptScore W3007897522C502942594 @default.
- W3007897522 hasConceptScore W3007897522C71924100 @default.
- W3007897522 hasConceptScore W3007897522C86803240 @default.
- W3007897522 hasConceptScore W3007897522C95444343 @default.
- W3007897522 hasIssue "9" @default.