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- W3007901201 abstract "The rat is an increasingly valuable model to study interventional therapeutic procedures. Suitable arterial access is essential for vascular intervention. In rats, transtail artery access has been recently reported as a feasible technique compared to conventional carotid or femoral access. The aim of this study was to evaluate repeat accessibility and complications of transtail angiography in a survival model. Seventeen male Sprague-Dawley rats were used (460.2 ± 45.0g), one rat died before the procedure, hence 16 rats were included in this study. 1-cm longitudinal ventral incisions were created 5 cm distal to the base of the tail to dissect the tail artery (ventral caudal artery). A 1.5–1.7 Fr microcatheter was advanced over a 0.010–0.014 inch microguidewire through a partial arteriotomy. Selective renal angiography was then performed. Intraarterial antibiotics injection was performed in 11 of 16 rats. The accessed segment of the tail artery was ligated and the incision closed with sutures. Repeat renal angiography via the tail artery was performed 48 hours after the initial procedure using a separate tail incision 1 cm proximal to the initial incision. Procedure time from skin incision to catheterization was recorded. Complications including tail ischemia, infection and bleeding were evaluated during the 2-day follow-up period. All initial and repeat procedures were successfully performed. The average time for the 32 tail artery cannulations was 11.0 ± 4.5 min. Transient focal skin color change in the tail was observed in one rat immediately after the initial procedure, which resolved within 90 mins. No tail necrosis, major bleeding or signs of infection were observed. Dehiscence of the incision was observed in 3 of 16 rats from self-grooming, with no bleeding or infection. Repeat tail artery access for angiography in rats was successful without major complications in a survival model. This reproducible technique can provide a new experimental platform to test transarterial procedures." @default.
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- W3007901201 date "2020-03-01" @default.
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- W3007901201 title "Abstract No. 438 Tail artery access for transarterial experiments in rats: feasibility study in a survival model" @default.
- W3007901201 doi "https://doi.org/10.1016/j.jvir.2019.12.499" @default.
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