Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007983094> ?p ?o ?g. }
- W3007983094 abstract "Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic polymorphisms, leads to the therapeutic failure of PQ as a radical cure for P. vivax malaria. Here, we hypothesized that the host immune response to malaria parasites modulates susceptibility to P. vivax recurrences in association with CYP2D6 activity." @default.
- W3007983094 created "2020-03-06" @default.
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- W3007983094 date "2020-04-21" @default.
- W3007983094 modified "2023-09-28" @default.
- W3007983094 title "Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence" @default.
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- W3007983094 doi "https://doi.org/10.1128/aac.02056-19" @default.
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