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• W3007996606 abstract "Formins direct the elongation of unbranched actin filaments by binding their barbed ends and processively stepping onto incoming actin monomers to incorporate them into the filament. Binding of profilin to actin monomers creates profilin–actin complexes, which then bind polyproline tracts located in formin homology 1 (FH1) domains. Diffusion of these natively disordered domains enables direct delivery of profilin–actin to the barbed end, speeding the rate of filament elongation. In this study, we investigated the mechanism of coordinated actin delivery from the multiple polyproline tracts in formin FH1 domains. We found that each polyproline tract can efficiently mediate polymerization, but that all tracts do not generate the same rate of elongation. In WT FH1 domains, the multiple polyproline tracts compete to deliver profilin–actin to the barbed end. This competition ultimately limits the rate of formin-mediated elongation. We propose that intrinsic properties of the filament-binding FH2 domain tune the efficiency of FH1-mediated elongation by directly regulating the rate of monomer incorporation at the barbed end. A strong correlation between competitive FH1-mediated profilin–actin delivery and FH2-regulated gating of the barbed end effectively limits the elongation rate, thereby obviating the need for evolutionary optimization of FH1 domain sequences." @default.
• W3007996606 created "2020-03-06" @default.
• W3007996606 creator A5038580996 @default.
• W3007996606 creator A5063501279 @default.
• W3007996606 date "2020-04-01" @default.
• W3007996606 modified "2023-10-17" @default.
• W3007996606 title "Competition for delivery of profilin–actin to barbed ends limits the rate of formin-mediated actin filament elongation" @default.
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• W3007996606 doi "https://doi.org/10.1074/jbc.ra119.012000" @default.
• W3007996606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7135983" @default.
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