FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008003485> ?p ?o ?g. }

• W3008003485 endingPage "141" @default.
• W3008003485 startingPage "131" @default.
• W3008003485 abstract "Excessive sebum is produced by specialized cells called sebocytes and is considered a cause or consequence of acne, sebaceous cysts, hyperplasia, and sebaceous adenoma.To report changes in lipid accumulation in human sebocytes under hypoxia, which occurs under conditions of seborrhea.Sebocytes from the immortalized human gland cell line SZ95 were cultured under conditions of hypoxia for 48 h; lipid formation was confirmed by Nile red and Oil Red O staining. To investigate whether HIF-1α plays a role in lipid accumulation, SZ95 cells transfected or treated with dimethyloxalylglycine (DMOG) were assessed by Nile red. For protein expression of the sterol regulatory element-binding protein-1 (SREBP-1) and perilipin 2 (PLIN2), Western blot analysis was performed. Differentially expressed genes (DEGs) in SZ95 sebocytes under hypoxia were revealed by RNA-Seq analyses, and the statistical significance of the correlation between hypoxic and acne/non-acne skin was evaluated using gene set enrichment analysis.Hypoxia induces lipid accumulation in SZ95 sebocytes. In addition, the levels of SREBP-1 and PLIN2 were regulated by HIF-1α in SZ95 sebocytes under hypoxia. RNA-Seq analyses of DEGs in SZ95 sebocytes under hypoxia revealed 256 DEGs, including several lipid droplet-associated genes. DEGs between acne and non-acne skin are significantly enriched in hypoxia gene sets. We also detected 93 differentially expressed inflammatory mediators.To the best of our knowledge, this study is the first to show that a hypoxic microenvironment can increase lipogenesis and provides a link between seborrhea and inflammation." @default.
• W3008003485 created "2020-03-06" @default.
• W3008003485 creator A5007042386 @default.
• W3008003485 creator A5051159507 @default.
• W3008003485 creator A5060550819 @default.
• W3008003485 creator A5082220016 @default.
• W3008003485 date "2020-02-21" @default.
• W3008003485 modified "2023-09-29" @default.
• W3008003485 title "Increased Lipid Accumulation under Hypoxia in SZ95 Human Sebocytes" @default.
• W3008003485 cites W1525008479 @default.
• W3008003485 cites W1557991089 @default.
• W3008003485 cites W1589763275 @default.
• W3008003485 cites W1946496343 @default.
• W3008003485 cites W1969646312 @default.
• W3008003485 cites W1984459676 @default.
• W3008003485 cites W1987202072 @default.
• W3008003485 cites W2001303796 @default.
• W3008003485 cites W2018008610 @default.
• W3008003485 cites W2031661874 @default.
• W3008003485 cites W2033571882 @default.
• W3008003485 cites W2036175833 @default.
• W3008003485 cites W2040116748 @default.
• W3008003485 cites W2053161927 @default.
• W3008003485 cites W2060174500 @default.
• W3008003485 cites W2060833045 @default.
• W3008003485 cites W2065357312 @default.
• W3008003485 cites W2072110036 @default.
• W3008003485 cites W2073101615 @default.
• W3008003485 cites W2087540265 @default.
• W3008003485 cites W2092039091 @default.
• W3008003485 cites W2092138194 @default.
• W3008003485 cites W2106391842 @default.
• W3008003485 cites W2118727162 @default.
• W3008003485 cites W2120129511 @default.
• W3008003485 cites W2130196988 @default.
• W3008003485 cites W2134562578 @default.
• W3008003485 cites W2138997208 @default.
• W3008003485 cites W2142492917 @default.
• W3008003485 cites W2143012469 @default.
• W3008003485 cites W2145098246 @default.
• W3008003485 cites W2152312852 @default.
• W3008003485 cites W2158217645 @default.
• W3008003485 cites W2158599779 @default.
• W3008003485 cites W2161085345 @default.
• W3008003485 cites W2165715419 @default.
• W3008003485 cites W2496428480 @default.
• W3008003485 cites W2535321036 @default.
• W3008003485 cites W2683693205 @default.
• W3008003485 cites W2736102942 @default.
• W3008003485 cites W2745237205 @default.
• W3008003485 cites W2752079152 @default.
• W3008003485 cites W2788914280 @default.
• W3008003485 doi "https://doi.org/10.1159/000505537" @default.
• W3008003485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32088721" @default.
• W3008003485 hasPublicationYear "2020" @default.
• W3008003485 type Work @default.
• W3008003485 sameAs 3008003485 @default.
• W3008003485 citedByCount "12" @default.
• W3008003485 countsByYear W30080034852021 @default.
• W3008003485 countsByYear W30080034852022 @default.
• W3008003485 countsByYear W30080034852023 @default.
• W3008003485 crossrefType "journal-article" @default.
• W3008003485 hasAuthorship W3008003485A5007042386 @default.
• W3008003485 hasAuthorship W3008003485A5051159507 @default.
• W3008003485 hasAuthorship W3008003485A5060550819 @default.
• W3008003485 hasAuthorship W3008003485A5082220016 @default.
• W3008003485 hasConcept C104317684 @default.
• W3008003485 hasConcept C121332964 @default.
• W3008003485 hasConcept C122927707 @default.
• W3008003485 hasConcept C126322002 @default.
• W3008003485 hasConcept C134018914 @default.
• W3008003485 hasConcept C141359234 @default.
• W3008003485 hasConcept C150194340 @default.
• W3008003485 hasConcept C171089720 @default.
• W3008003485 hasConcept C178790620 @default.
• W3008003485 hasConcept C185592680 @default.
• W3008003485 hasConcept C25095133 @default.
• W3008003485 hasConcept C2776175234 @default.
• W3008003485 hasConcept C2777074287 @default.
• W3008003485 hasConcept C2777363609 @default.
• W3008003485 hasConcept C2778086801 @default.
• W3008003485 hasConcept C2780806160 @default.
• W3008003485 hasConcept C39567582 @default.
• W3008003485 hasConcept C4733338 @default.
• W3008003485 hasConcept C540031477 @default.
• W3008003485 hasConcept C54355233 @default.
• W3008003485 hasConcept C55493867 @default.
• W3008003485 hasConcept C62520636 @default.
• W3008003485 hasConcept C71924100 @default.
• W3008003485 hasConcept C7836513 @default.
• W3008003485 hasConcept C81885089 @default.
• W3008003485 hasConcept C85051948 @default.
• W3008003485 hasConcept C86803240 @default.
• W3008003485 hasConcept C91881484 @default.
• W3008003485 hasConcept C95444343 @default.
• W3008003485 hasConceptScore W3008003485C104317684 @default.
• W3008003485 hasConceptScore W3008003485C121332964 @default.
• W3008003485 hasConceptScore W3008003485C122927707 @default.

• next