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- W3008010068 abstract "Microsporidia are found worldwide and both vertebrates and invertebrates can serve as hosts for these organisms. While microsporidiosis in humans can occur in both immune competent and immune compromised hosts, it has most often been seen in the immune suppressed population, e.g. patients with advanced HIV infection, patients who have had organ transplantation, those undergoing chemotherapy, or patients using other immune suppressive agents. Infection can be associated with either focal infection in a specific organ (e.g. keratoconjunctivitis, cerebritis, or hepatitis) or with disseminated disease. The most common presentation of microsporidiosis being gastrointestinal infection with chronic diarrhea and wasting syndrome. In the setting of advanced HIV infection or other cases of profound immune deficiency microsporidiosis can be extremely debilitating and carries a significant mortality risk. Microsporidia are transmitted as spores which invade host cells by a specialized invasion apparatus the polar tube. This review summarizes recent studies that have provided information on the composition of the spore wall and polar tube, as well as insights into the mechanism of invasion and interaction of the polar tube and spore wall with host cells during infection." @default.
- W3008010068 created "2020-03-06" @default.
- W3008010068 creator A5047300604 @default.
- W3008010068 creator A5066856917 @default.
- W3008010068 creator A5091275779 @default.
- W3008010068 date "2020-02-18" @default.
- W3008010068 modified "2023-10-18" @default.
- W3008010068 title "Invasion of Host Cells by Microsporidia" @default.
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