FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008049779> ?p ?o ?g. }

• W3008049779 endingPage "109905" @default.
• W3008049779 startingPage "109905" @default.
• W3008049779 abstract "Nasopharyngeal carcinoma (NPC) is common in Southern China. The molecular mechanism underlying NPC genesis and progression has been comprehensively investigated, but the key gene (s) or pathway (s) pertaining to NPC are unidentified. We explored some key genes and pathways involved in NPC through using meta-analysis of deposited expression of microarray data of NPC. The expression of proliferating cell nuclear antigen clamp associated factor (PCLAF) was determined by real-time PCR and western blots. CCK-8 assay, colony formation assay, transwell migration assay, cell wound healing assay, cell cycle analysis and cell apoptosis were carried out to assess biological behaviors caused by downregulation and overexpression of PCLAF in vitro. CHIP was utilized to determine the direct upstream regulatory transcription factors of PCLAF. PCLAF was the key gene of NPC, which was significantly up-regulated in NPC cell line compared to the normal nasopharyngeal cell line. Additionally, in vitro assay has demonstrated the down-regulation and overexpression of PCLAF, resulted in significantly suppressed and enhanced NPC proliferation, metastasis and invasion respectively. Furthermore, the up-regulation of PCLAF in NPC is induced by direct binding of dysregulated NF-κB p50/RelB complex to the promoter of PCLAF. Our results offer a strategy for re-using the deposited data to find the key genes and pathways involved in pathogenesis of cancer. Our study has provided evidence of supporting the role of PCLAF in NPC genesis and progression." @default.
• W3008049779 created "2020-03-06" @default.
• W3008049779 creator A5006860535 @default.
• W3008049779 creator A5017220676 @default.
• W3008049779 creator A5025981864 @default.
• W3008049779 creator A5026802483 @default.
• W3008049779 creator A5027516492 @default.
• W3008049779 creator A5028349844 @default.
• W3008049779 creator A5034316277 @default.
• W3008049779 creator A5038263382 @default.
• W3008049779 creator A5044188620 @default.
• W3008049779 creator A5051011891 @default.
• W3008049779 creator A5064644247 @default.
• W3008049779 creator A5076800713 @default.
• W3008049779 creator A5077410494 @default.
• W3008049779 creator A5079524559 @default.
• W3008049779 creator A5080113918 @default.
• W3008049779 creator A5086326013 @default.
• W3008049779 creator A5086473866 @default.
• W3008049779 date "2020-05-01" @default.
• W3008049779 modified "2023-10-03" @default.
• W3008049779 title "Dysregulated NF-κB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis" @default.
• W3008049779 cites W1566831845 @default.
• W3008049779 cites W1629202041 @default.
• W3008049779 cites W1967727795 @default.
• W3008049779 cites W1968130213 @default.
• W3008049779 cites W1987584325 @default.
• W3008049779 cites W1997360704 @default.
• W3008049779 cites W2030311708 @default.
• W3008049779 cites W2058169032 @default.
• W3008049779 cites W2090255529 @default.
• W3008049779 cites W2091747793 @default.
• W3008049779 cites W2104930726 @default.
• W3008049779 cites W2106299774 @default.
• W3008049779 cites W2111837579 @default.
• W3008049779 cites W2118258530 @default.
• W3008049779 cites W2128666412 @default.
• W3008049779 cites W2142337569 @default.
• W3008049779 cites W2153679407 @default.
• W3008049779 cites W2338910578 @default.
• W3008049779 cites W2502754259 @default.
• W3008049779 cites W2522155417 @default.
• W3008049779 cites W2557585729 @default.
• W3008049779 cites W2576208023 @default.
• W3008049779 cites W2888502404 @default.
• W3008049779 doi "https://doi.org/10.1016/j.biopha.2020.109905" @default.
• W3008049779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32070873" @default.
• W3008049779 hasPublicationYear "2020" @default.
• W3008049779 type Work @default.
• W3008049779 sameAs 3008049779 @default.
• W3008049779 citedByCount "7" @default.
• W3008049779 countsByYear W30080497792021 @default.
• W3008049779 countsByYear W30080497792022 @default.
• W3008049779 countsByYear W30080497792023 @default.
• W3008049779 crossrefType "journal-article" @default.
• W3008049779 hasAuthorship W3008049779A5006860535 @default.
• W3008049779 hasAuthorship W3008049779A5017220676 @default.
• W3008049779 hasAuthorship W3008049779A5025981864 @default.
• W3008049779 hasAuthorship W3008049779A5026802483 @default.
• W3008049779 hasAuthorship W3008049779A5027516492 @default.
• W3008049779 hasAuthorship W3008049779A5028349844 @default.
• W3008049779 hasAuthorship W3008049779A5034316277 @default.
• W3008049779 hasAuthorship W3008049779A5038263382 @default.
• W3008049779 hasAuthorship W3008049779A5044188620 @default.
• W3008049779 hasAuthorship W3008049779A5051011891 @default.
• W3008049779 hasAuthorship W3008049779A5064644247 @default.
• W3008049779 hasAuthorship W3008049779A5076800713 @default.
• W3008049779 hasAuthorship W3008049779A5077410494 @default.
• W3008049779 hasAuthorship W3008049779A5079524559 @default.
• W3008049779 hasAuthorship W3008049779A5080113918 @default.
• W3008049779 hasAuthorship W3008049779A5086326013 @default.
• W3008049779 hasAuthorship W3008049779A5086473866 @default.
• W3008049779 hasBestOaLocation W30080497791 @default.
• W3008049779 hasConcept C104317684 @default.
• W3008049779 hasConcept C121608353 @default.
• W3008049779 hasConcept C126322002 @default.
• W3008049779 hasConcept C127561419 @default.
• W3008049779 hasConcept C150194340 @default.
• W3008049779 hasConcept C190283241 @default.
• W3008049779 hasConcept C2778997737 @default.
• W3008049779 hasConcept C2779013556 @default.
• W3008049779 hasConcept C29537977 @default.
• W3008049779 hasConcept C502942594 @default.
• W3008049779 hasConcept C509974204 @default.
• W3008049779 hasConcept C54355233 @default.
• W3008049779 hasConcept C62112901 @default.
• W3008049779 hasConcept C71924100 @default.
• W3008049779 hasConcept C81885089 @default.
• W3008049779 hasConcept C8415881 @default.
• W3008049779 hasConcept C86803240 @default.
• W3008049779 hasConceptScore W3008049779C104317684 @default.
• W3008049779 hasConceptScore W3008049779C121608353 @default.
• W3008049779 hasConceptScore W3008049779C126322002 @default.
• W3008049779 hasConceptScore W3008049779C127561419 @default.
• W3008049779 hasConceptScore W3008049779C150194340 @default.
• W3008049779 hasConceptScore W3008049779C190283241 @default.
• W3008049779 hasConceptScore W3008049779C2778997737 @default.
• W3008049779 hasConceptScore W3008049779C2779013556 @default.

• next