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• W3008115903 endingPage "134861" @default.
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• W3008115903 abstract "Abstract Ototoxic drugs may induce auditory sensory hair cell loss and permanent deafness; however, there is still no effective treatments or prevention strategies for this side effect. A recent study found that microRNA182 (miR-182) protected cochlear hair cells from ototoxic drug-induced apoptosis in vitro. However, it remains unclear whether miR-182 can protect drug-induced deafness in vivo. In this study, we overexpressed cochlear miR-182 in Sprague-Dawley rats by trans-round window niche delivery of miR-182 mimics. The rats subsequently received intraperitoneal injections of kanamycin and furosemide to induce acute cochlear outer hair cell death and permanent deafness. Auditory brainstem response tests showed that miR-182 attenuated permanent threshold shifts. Consistent with this result, miR-182 reduced the loss of outer hair cells and missing stereocilia. miR-182 treatment also increased the level of phosphoinositide-3 kinase regulatory subunit p85α in the outer hair cells after co-administration of kanamycin and furosemide. Our findings suggest that miR-182 has powerful protective potential against ototoxic drug-induced acute auditory sensory hair cell loss and permanent deafness." @default.
• W3008115903 created "2020-03-06" @default.
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• W3008115903 date "2020-04-01" @default.
• W3008115903 modified "2023-10-18" @default.
• W3008115903 title "miR-182 prevented ototoxic deafness induced by co-administration of kanamycin and furosemide in rats" @default.
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• W3008115903 doi "https://doi.org/10.1016/j.neulet.2020.134861" @default.
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