Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008273325> ?p ?o ?g. }
- W3008273325 endingPage "L761" @default.
- W3008273325 startingPage "L750" @default.
- W3008273325 abstract "The adaptive immune response could play a major role in the resolution of lung injury. Although regulatory T cells (Tregs) have been implicated in promoting the resolution of lung injury, therapeutic strategies to enhance Treg quantity and activity at the site of injury need further exploration. In the current study, Akt inhibition using triciribine (TCBN), given 48 h after lipopolysaccharide (LPS) administration, increased Tregs-promoted resolution of acute lung injury (ALI). TCBN treatment enhanced the resolution of LPS-induced ALI on day 7 by reducing pulmonary edema and neutrophil activity associated with an increased number of CD4 + /FoxP3 + /CD103 + and CTLA4 + effector Tregs, specifically in the injured lungs and not in the spleen. Treatment of EL-4 T-lymphocytes with two Akt inhibitors (TCBN and MK-2206) for 72 h resulted in increased FoxP3 expression in vitro. On the other end, Treg-specific PTEN knockout (PTEN Treg KO) mice that have a higher Akt activity in its Tregs exhibited a significant impairment in ALI resolution, increased edema, and neutrophil activity associated with a reduced number of CD4 + /FoxP3 + /CD103 + and CTLA4 + effector Tregs as compared with the control group. In conclusion, our study identifies a potential target for the treatment of late-stage ALI by promoting resolution through effector Treg-mediated suppression of inflammation." @default.
- W3008273325 created "2020-03-06" @default.
- W3008273325 creator A5007987021 @default.
- W3008273325 creator A5011462362 @default.
- W3008273325 creator A5034451660 @default.
- W3008273325 creator A5042509710 @default.
- W3008273325 creator A5052840597 @default.
- W3008273325 creator A5071358448 @default.
- W3008273325 creator A5088952922 @default.
- W3008273325 date "2020-04-01" @default.
- W3008273325 modified "2023-10-01" @default.
- W3008273325 title "Delayed Akt suppression in the lipopolysaccharide-induced acute lung injury promotes resolution that is associated with enhanced effector regulatory T cells" @default.
- W3008273325 cites W1945156854 @default.
- W3008273325 cites W1961536135 @default.
- W3008273325 cites W1969937534 @default.
- W3008273325 cites W1977336621 @default.
- W3008273325 cites W1978633564 @default.
- W3008273325 cites W1992662011 @default.
- W3008273325 cites W1994566639 @default.
- W3008273325 cites W2003257616 @default.
- W3008273325 cites W2003476505 @default.
- W3008273325 cites W2038689503 @default.
- W3008273325 cites W2042844150 @default.
- W3008273325 cites W2058864165 @default.
- W3008273325 cites W2063241227 @default.
- W3008273325 cites W2072853625 @default.
- W3008273325 cites W2086194617 @default.
- W3008273325 cites W2094536853 @default.
- W3008273325 cites W2101019828 @default.
- W3008273325 cites W2110379870 @default.
- W3008273325 cites W2112272226 @default.
- W3008273325 cites W2124645233 @default.
- W3008273325 cites W2126698946 @default.
- W3008273325 cites W2135838271 @default.
- W3008273325 cites W2146226755 @default.
- W3008273325 cites W2151856750 @default.
- W3008273325 cites W2152575820 @default.
- W3008273325 cites W2161981173 @default.
- W3008273325 cites W2202295242 @default.
- W3008273325 cites W2286228001 @default.
- W3008273325 cites W2343577193 @default.
- W3008273325 cites W2406887252 @default.
- W3008273325 cites W2433064503 @default.
- W3008273325 cites W2548097234 @default.
- W3008273325 cites W2571705430 @default.
- W3008273325 cites W2603231568 @default.
- W3008273325 cites W2616234418 @default.
- W3008273325 cites W2623353693 @default.
- W3008273325 cites W2770476385 @default.
- W3008273325 cites W2799690174 @default.
- W3008273325 cites W2907960865 @default.
- W3008273325 cites W4210474263 @default.
- W3008273325 cites W4237939525 @default.
- W3008273325 doi "https://doi.org/10.1152/ajplung.00251.2019" @default.
- W3008273325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7191478" @default.
- W3008273325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32073894" @default.
- W3008273325 hasPublicationYear "2020" @default.
- W3008273325 type Work @default.
- W3008273325 sameAs 3008273325 @default.
- W3008273325 citedByCount "21" @default.
- W3008273325 countsByYear W30082733252020 @default.
- W3008273325 countsByYear W30082733252021 @default.
- W3008273325 countsByYear W30082733252022 @default.
- W3008273325 countsByYear W30082733252023 @default.
- W3008273325 crossrefType "journal-article" @default.
- W3008273325 hasAuthorship W3008273325A5007987021 @default.
- W3008273325 hasAuthorship W3008273325A5011462362 @default.
- W3008273325 hasAuthorship W3008273325A5034451660 @default.
- W3008273325 hasAuthorship W3008273325A5042509710 @default.
- W3008273325 hasAuthorship W3008273325A5052840597 @default.
- W3008273325 hasAuthorship W3008273325A5071358448 @default.
- W3008273325 hasAuthorship W3008273325A5088952922 @default.
- W3008273325 hasBestOaLocation W30082733252 @default.
- W3008273325 hasConcept C203014093 @default.
- W3008273325 hasConcept C2776090121 @default.
- W3008273325 hasConcept C2776914184 @default.
- W3008273325 hasConcept C2777609662 @default.
- W3008273325 hasConcept C2778296632 @default.
- W3008273325 hasConcept C2778754761 @default.
- W3008273325 hasConcept C2779727006 @default.
- W3008273325 hasConcept C502942594 @default.
- W3008273325 hasConcept C51785407 @default.
- W3008273325 hasConcept C62478195 @default.
- W3008273325 hasConcept C71924100 @default.
- W3008273325 hasConcept C75217442 @default.
- W3008273325 hasConcept C79484868 @default.
- W3008273325 hasConcept C86554907 @default.
- W3008273325 hasConcept C86803240 @default.
- W3008273325 hasConcept C8891405 @default.
- W3008273325 hasConcept C95444343 @default.
- W3008273325 hasConceptScore W3008273325C203014093 @default.
- W3008273325 hasConceptScore W3008273325C2776090121 @default.
- W3008273325 hasConceptScore W3008273325C2776914184 @default.
- W3008273325 hasConceptScore W3008273325C2777609662 @default.
- W3008273325 hasConceptScore W3008273325C2778296632 @default.
- W3008273325 hasConceptScore W3008273325C2778754761 @default.
- W3008273325 hasConceptScore W3008273325C2779727006 @default.
- W3008273325 hasConceptScore W3008273325C502942594 @default.