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- W3008287718 abstract "BackgroundThe use of implanted medical devices is associated with a small but clinically important risk of foreign body infection. A key question is: why do some patients develop chronic infection associated with an implanted device, but most do not?AimsThe literature on patient-specific risk factors for chronic infections associated with five types of implants was surveyed to glean clues about the etiology of these infections.SourcesData were collected from 47 articles through calendar year 2017 for five categories of device-related infections: cardiovascular implantable electronic devices (CIEDs), hernia meshes, prosthetic hip and knee joints, prosthetic shoulder joints and breast implants.ContentImportant risk factors include immunomodulation/steroid therapy, diabetes, smoking, and renal disease/haemodialysis—findings that point to a critical role of a compromised innate immune response in determining vulnerable subpopulations.ImplicationsA model of biofilm-related device infection is presented that posits defects in the innate immune response both systemically and locally, in the immediate vicinity of an abiotic biomaterial. The limitations of in vitro and animal models of chronic device-related infections are discussed in this context as are implications for research and clinical practice." @default.
- W3008287718 created "2020-03-06" @default.
- W3008287718 creator A5003553464 @default.
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- W3008287718 date "2020-08-01" @default.
- W3008287718 modified "2023-10-17" @default.
- W3008287718 title "Risk factors for chronic biofilm-related infection associated with implanted medical devices" @default.
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- W3008287718 doi "https://doi.org/10.1016/j.cmi.2020.02.027" @default.
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