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• W3008317503 startingPage "104547" @default.
• W3008317503 abstract "Pesticide residue is a common problem worldwide. Cypermethrin is a type II pyrethroid pesticide that has been widely used in recent years. It has become a widespread residual pesticide in the environment and agricultural products. The neurotoxicity of cypermethrin remains a matter of concern. However, few studies have evaluated its toxicity on cerebral cortical neurons. As the center of the nervous system, the cerebral cortex is involved in a series of biological processes, such as learning, memory, emotions, and movement. The Nrf2/ARE signaling pathway has been considered to play a protective role in several central nervous system (CNS) diseases. We investigated whether this pathway plays a protective role in cypermethrin-induced apoptosis of the cortical neurons. We established a cypermethrin-induced apoptosis model in the cortical neurons using different cypermethrin doses and different incubation periods. The changes in Nrf2 protein and mRNA expression and its downstream genes HO-1 and NQO1 were detected by quantitative real-time PCR and Western blotting to study the role of the Nrf2/ARE pathway in cypermethrin-induced apoptosis of the cortical neurons. The results showed that the Nrf2/ARE signaling pathway has a protective effect in cypermethrin-induced apoptosis of the cortical neurons. However, this protective effect of the Nrf2/ARE pathway is very limited and is dependent on the exposure dose and exposure period of cypermethrin." @default.
• W3008317503 created "2020-03-06" @default.
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• W3008317503 date "2020-05-01" @default.
• W3008317503 modified "2023-10-18" @default.
• W3008317503 title "Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway" @default.
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• W3008317503 doi "https://doi.org/10.1016/j.pestbp.2020.02.013" @default.
• W3008317503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32359539" @default.
• W3008317503 hasPublicationYear "2020" @default.
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